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Clinical risk

Papers on clinical risk

1,010 papers131 new in 30 days

Friday, October 16

Wednesday, October 14

European Radiology

Silent spinal fractures were common in UK Biobank adults

Scans identified moderate or severe spinal fractures in 14.6% of 2,446 symptom-free UK Biobank participants aged 40–79, including people with normal bone density.Scans identified moderate or severe spinal fractures in 14.6% of 2,446 symptom-free UK Biobank participants aged 40–79, including people with normal bone density.

Figure from European Radiology
Cross-sectional · 2,446 peopleBones and joints
Paper

Tuesday, October 13

medRxiv

Stiffer main arteries linked to higher estimated stress in people

An observational analysis of scans from 57,434 UK Biobank participants linked stiffness, as well as artery size, to estimated stress within the aorta's wall.An observational analysis of scans from 57,434 UK Biobank participants linked stiffness, as well as artery size, to estimated stress within the aorta's wall.

An overview of the methodology for (a) distensibility and (b) stress analyses.
Preprint: cross-sectional study of 57,434 peoplePopulations
Paper
medRxiv

Main artery calcium linked to risk despite normal heart scans

Higher calcium in the main artery was linked to cardiovascular death, heart attack or heart failure admission in 3,580 patients followed for a median 52 months.Higher calcium in the main artery was linked to cardiovascular death, heart attack or heart failure admission in 3,580 patients followed for a median 52 months.

Study overview. AAC=ascending aortic calcification.
Preprint: cohort study of 21,923 peopleBiomarkers
Paper

Sunday, October 11

Saturday, October 10

The American Journal of Clinical Nutrition

Mediterranean lifestyle linked to lower risk of death

The highest-scoring quarter had a hazard ratio of 0.70—a measure comparing death rates over time—versus the lowest-scoring quarter.The highest-scoring quarter had a hazard ratio of 0.70—a measure comparing death rates over time—versus the lowest-scoring quarter.

Figure from The American Journal of Clinical Nutrition
Cohort study of 105,812 peoplePopulations
Paper

Friday, October 9

Thursday, October 8

medRxiv

DNA score modestly improves death risk prediction in people

At 10 years, a measure of predictive performance rose from 0.791 for the clinical model to 0.803 when researchers added the DNA score.At 10 years, a measure of predictive performance rose from 0.791 for the clinical model to 0.803 when researchers added the DNA score.

Cohort Inclusion Criteria.
Preprint: cohort study of 2,282 peopleBiomarkers
Paper

Wednesday, October 7

Medicine and Science in Sports and Exercise

Treadmill fitness improved ten-year death risk predictions

A model’s score for distinguishing higher from lower death risk rose from 0.662 using traditional risk factors alone to 0.682 after adding treadmill fitness.A model’s score for distinguishing higher from lower death risk rose from 0.662 using traditional risk factors alone to 0.682 after adding treadmill fitness.

A group of upright, faceless adults surrounds a person walking on a treadmill, with large lungs and a smaller heart above them.
Cohort study of 562,234 peopleBiomarkers
Paper
Aging

DNA aging markers linked to social disparities in mortality

GrimAge2, a DNA-based aging measure, statistically accounted for up to 52% of associations between social factors and deaths from any cause.GrimAge2, a DNA-based aging measure, statistically accounted for up to 52% of associations between social factors and deaths from any cause.

Raw correlation matrix of potential mediators and age in NHANES 1999–2002 (n = 2,402).
Cohort study of 2,402 peopleBiomarkers
Paper

Tuesday, October 6

bioRxiv

Blood protein clock tracks shifts in health risks over time

In an observational study of 4,100 people, accelerated blood protein aging tracked worsening kidney function, blood lipid imbalances, and a higher risk of death.In an observational study of 4,100 people, accelerated blood protein aging tracked worsening kidney function, blood lipid imbalances, and a higher risk of death.

Overview. a KORA proteomics cohort: timepoints S4 and the two follow-up time points F4 and FF4 and their numbers of samples.
Preprint: cohort study of 4,100 peopleBiomarkers
Paper

Friday, October 2

Cyborg and Bionic Systems

Language model multimorbidity score predicts mortality in adults

Across eight external cohorts, the score yielded C-indices of 0.67 to 0.86, outperforming recalibrated conventional comorbidity indices by absolute gains of 0.12 to 0.21.Across eight external cohorts, the score yielded C-indices of 0.67 to 0.86, outperforming recalibrated conventional comorbidity indices by absolute gains of 0.12 to 0.21.

Overview of the LLM-MMS: global validation, robustness assessment, and generation framework.
Cohort study of 770,439 peopleMultimorbidity
Paper

Thursday, October 1

Wednesday, September 30