Major osteoporotic fractures
Disease2 papers2 findings
- Humans2
Associations
2M5
upin humans1
1 study
M5
upin humans1
M5 predicts major osteoporotic fractures in humans (10-year ΔAUC + 0.052, 95% CI + 0.023 to + 0.080).
Humansin menmalesn = 5,994
Physical performance predicts fracture risk in older adults · Calcified tissue international · 1 Oct 2026
GIPR
downin humans1OR 0.8
1 study
GIPR
downin humans1OR 0.8
GIPR lowers the risk of major osteoporotic fractures in humans (OR 0.80, 95% CI 0.66-0.98).
Humansscaled to lower BMI
Genetically proxied GIP pathway links to lower fracture risk · Diabetes, obesity & metabolism · 29 Sep 2026
Latest
3Physical performance predicts fracture risk in older adults
In older men, a five-variable physical model beat FRAX without bone scans, raising 10-year fracture discrimination by an area under the curve of…In older men, a five-variable physical model beat FRAX without bone scans, raising 10-year fracture discrimination by an area under the curve of 0.052.
Genetically proxied GIP pathway links to lower fracture risk
Scaled to lower BMI, genetically proxied GIP-GIPR perturbation tracked with lower odds of major osteoporotic fractures (OR 0.80) and spine-and-hip…Scaled to lower BMI, genetically proxied GIP-GIPR perturbation tracked with lower odds of major osteoporotic fractures (OR 0.80) and spine-and-hip fractures (OR 0.68).