Amyloid-beta accumulation

1. Fluphenazine decreases amyloid-beta accumulation in worms.

   “fluphenazine reduced amyloid-beta accumulation”

   Model organismsin a Caenorhabditis elegans model of Alzheimer's disease

   Fluphenazine, an antipsychotic compound, ameliorates Alzheimer's disease by clearing amyloid beta accumulation in C. elegans

   GeroScience·9 Sep 2025

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1. Age increases amyloid-beta accumulation in humans.

   “increasing with age in the upper percentiles”

   Humanscognitively unimpaired participantsbrain

   Age-related amyloid beta dynamics modeled with the generalized additive model for location, scale, and shape (GAMLSS) across diverse populations: Cross-sectional trajectories and longitudinal validation

   Alzheimer's & dementia : the journal of the Alzheimer's Association·1 Sep 2025

1. Hyperlipidemia is associated with amyloid-beta accumulation in humans (OR = 1.83, p = .047).

   “hyperlipidemia was associated with a 1.8 x higher likelihood of greater than expected Aβ for age (OR = 1.83, p = .047)”

   HumansDown syndromebrainn = 262

   Cardiovascular Risk Composite and Time of Amyloid Accumulation and Cognitive Decline in Down Syndrome Alzheimer's Disease

   AAIC 2025 abstract·24 Dec 2025

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1. Cardiovascular risk composite is associated with amyloid-beta accumulation in humans (r = .156, p = .016).

   “there was a significant positive association between the cardiovascular composite ( r = .156, p = .016) and resistance score; higher cardiovascular composite was associated with greater than expected Aβ for age”

   HumansDown syndromebrainn = 262

   Cardiovascular Risk Composite and Time of Amyloid Accumulation and Cognitive Decline in Down Syndrome Alzheimer's Disease

   AAIC 2025 abstract·24 Dec 2025

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1. APOE is associated with amyloid-beta accumulation in humans.

   “NHWs exhibited steeper Aβ accumulation trajectories, particularly among APOE ε4 carriers.”

   Humanscognitively unimpaired non-Hispanic White vs Korean participantsbrain

   Age-related amyloid beta dynamics modeled with the generalized additive model for location, scale, and shape (GAMLSS) across diverse populations: Cross-sectional trajectories and longitudinal validation

   Alzheimer's & dementia : the journal of the Alzheimer's Association·1 Sep 2025

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