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No phaseRecruitingGeroscience intervention

PRecision gerOMedicinE: Tailored Healthy agEing With Lifestyle, sUpplements and drugS (PROMETHEUS)

Sponsor
National University of Singapore (Academic or other)
Enrolment
20 planned
Conditions
Ageing
Interventions
Sleep and dietary counseling; Supervised exercise and exergaming program; Motivational interviewing; Whey protein; Creatine Monohydrate; Fucoidan; Urolithin A; Nicotinamide Mononucleotide (NMN); Multivitamin; Ergothioneine
Ages
adults, older adults
Registry
NCT07451496

Full record on ClinicalTrials.gov

From the registry

As the population ages, the growing prevalence of age-related diseases is creating substantial challenges for healthcare systems worldwide. Current therapeutic strategies often target individual diseases and decrease mortality without improving healthspan. The geroscience hypothesis suggests that targeting the ageing process itself could prevent, delay, or manage the severity of multiple age-related diseases concurrently, thereby improving overall healthspan and reducing healthcare burdens. Emerging research highlights several interconnected hallmarks of aging, such as mitochondrial dysfunction, chronic inflammation, impaired autophagy, and immune dysregulation, as modifiable through targeted interventions. Precision geromedicine represents a paradigm shift in addressing these processes, combining baseline diagnostics with individualized treatment strategies that adapt over time based on patient response. This approach integrates lifestyle modifications, dietary supplements, and pharmacological agents to optimize physical, cognitive, and immune function across the lifespan .

Primary outcomes

  • Change from baseline in cardiorespiratory fitness (VO₂peak)
  • Change from baseline in muscle strength (one-repetition maximum (1RM))
  • Change from baseline in muscle mass (Ultrasound imaging)
  • Change from baseline in cognitive performance (NIH Toolbox Fluid Cognition Composite)

History

  1. Study completion

  2. Registered

  3. Primary completion

  4. Started