Cardiovascular Risk Composite and Time of Amyloid Accumulation and Cognitive Decline in Down Syndrome Alzheimer's Disease

Abstract

Background: Individuals with Down syndrome (DS) have a 90% lifetime risk for symptomatic Alzheimer's disease. Yet, there is a 20+ year age range in when individuals with DS reach PET amyloid‐beta (Aβ) positivity (i.e., centiloid (CL) ≥18). There is a critical need to identify factors associated with resistance (i.e.