bioRxiv
Excess cell size drives senescence by altering RNA in cells
Experiments in cultured cells show that cell enlargement reorganizes DNA and alters RNA splicing, while restoring a single protein variant resumes cell division.Experiments in cultured cells show that cell enlargement reorganizes DNA and alters RNA splicing, while restoring a single protein variant resumes cell division.
Preprint: human cell studyCellular senescence
Who was studiedHTERT-RPE1 cells, 7 days, against size-constrained cells
What changedNonfunctional MDM4 RNA's share rose >9-fold in enlarged cells compared with size-constrained cells
The catchRNA decay likely caused underestimation of the nonfunctional MDM4 transcript's production
