What does the research say about altered gene expression?

Altered gene expression

There is 1 paper on altered gene expression in aging research: none in people yet, 1 in animals. The newest story, Oct 22, 2026: “Excess cell size drives senescence by altering RNA in cells”.

Biomarker

1 paper studies it168 more mention it1 finding

3 new papers in 30 daysSee all 169 papers on altered gene expression

Animals1

Interventions

Fisetin

downin zebrafish1

1 study

Fisetin decreases altered gene expression in cdkl5-/- larvae (normalization).
“Fisetin demonstrated the most consistent phenotypic improvement, including partial restoration of craniofacial abnormalities and normalization of gene expression levels.”
Animalsin cdkl5-/- larvae
Rescuing functional defects in a zebrafish model of CDKL5 deficiency disorder: Contribution to the identification of new therapeutic compounds
bioRxivMar 16, 2026Preprint

Latest

28 papers in 12 months

bioRxivMar 16

Rescuing functional defects in a zebrafish model of CDKL5 deficiency disorder: Contribution to the identification of new therapeutic compounds

Preprint: experiments in zebrafishInterventions

Paper

Research SquareNov 4

Selinexor, a CRM1 inhibitor with anti-senescence activity, modulates the non- coding transcriptome of Hutchinson–Gilford progeria syndrome fibroblasts

Preprint: experiments in human cellsCellular senescence

Paper

bioRxivNov 3

A conserved pituitary response to tissue loss controls regeneration across vertebrates

Preprint: experiments in miceMechanisms

Paper

bioRxivOct 22

Excess cell size drives senescence by altering RNA in cells

Experiments in cultured cells show that cell enlargement reorganizes DNA and alters RNA splicing, while restoring a single protein variant resumes cell division.Experiments in cultured cells show that cell enlargement reorganizes DNA and alters RNA splicing, while restoring a single protein variant resumes cell division.

Preprint: human cell studyCellular senescence

Paper

Trends in Molecular MedicineSep 11

Telomerase reverse transcriptase as a core regulator of brain health

CommentaryEpigenetic regulation of gene expression

Paper

Research SquareSep 3

Older mice had tighter DNA packing in light-sensing cells

Comparisons of young and aged mouse rod cells linked changes in DNA packaging to altered gene activity, particularly in active regions of the genome.Comparisons of young and aged mouse rod cells linked changes in DNA packaging to altered gene activity, particularly in active regions of the genome.

Preprint: cross-sectional studyMechanisms