Ageing markers

Biomarker

2 papers2 findings

Animals1
Model organisms1

Interventions

GNF-5837

downin animals1

1 study

GNF-5837 decreases ageing markers.
“GNF-5837 reduced the expression of ageing markers by upregulating GPX7”
Animals
GNF-5837 alleviates intervertebral disc ageing by upregulating glutathione peroxidase 7
International journal of immunopathology and pharmacology6 Jun 2025

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120 in 12 months

medRxivYesterday

Biological aging markers in South African women with HIV and variable exposure to childhood maltreatment

Preprint: cross-sectional study of 238 peoplePopulations

Paper

International Journal of Molecular SciencesYesterday

Epitalon and Epithalamin: A Narrative Review of Mechanistic, Preclinical, and Clinical Evidence

ReviewInterventions

Paper

Biochimica et Biophysica Acta Molecular Basis of Disease14 Oct

Low cell-attachment protein levels linked to heart aging in mice

Mice with one working copy of the protein’s gene had enlarged, scarred hearts and poorer pumping, resembling changes in aged mice.Mice with one working copy of the protein’s gene had enlarged, scarred hearts and poorer pumping, resembling changes in aged mice.

Experiments in aged and Cdon+/- miceMechanisms

Limit: Whether changing CDON affects heart aging in people remains untested

Paper

Research Square9 Oct

Estimated brain-age gap rises by three years in pregnancy

Brain-age gap estimates rose by about three years during pregnancy and fell below pre-conception levels by 16 months postpartum in a longitudinal study.Brain-age gap estimates rose by about three years during pregnancy and fell below pre-conception levels by 16 months postpartum in a longitudinal study.

Preprint: cohort study of 340 peoplePopulations

Paper

Aging8 Oct

Body composition, but not morphological masculinity, is associated with biological aging markers in middle-aged men

Cross-sectional study of 176 peoplePopulations

Paper

GeroScience7 Oct

Sweet-tooth preferences were linked to higher dementia risk

The sweet-tooth group had a 79% higher dementia risk than the group labelled health-aligned in a prospective cohort study.The sweet-tooth group had a 79% higher dementia risk than the group labelled health-aligned in a prospective cohort study.

Cohort study in peopleVascular dementia

Paper

medRxiv6 Oct

Hormone therapy linked to lower breast cancer mortality

Compared with never-users, hormone therapy ever-users had adjusted hazard ratios, which compare event rates over time, of 0.72 for breast cancer death and 1.17 for…Compared with never-users, hormone therapy ever-users had adjusted hazard ratios, which compare event rates over time, of 0.72 for breast cancer death and 1.17 for diagnosis.

Preprint: cohort study of 78,209 peopleBreast cancer

Paper

Journal of Electrocardiology1 Oct

Electrocardiogram heart age reflects past electrical burden but not future aging pace

Researchers analyzed serial electrocardiograms from over 128,000 patients to distinguish cumulative cardiac aging damage from the rate of future electrical changes.Researchers analyzed serial electrocardiograms from over 128,000 patients to distinguish cumulative cardiac aging damage from the rate of future electrical changes.

Cohort study of 128,605 peopleBiomarkers

Paper

Alzheimer's & Dementia29 Sep

Biological aging clocks combined with genetics improve dementia risk prediction

Adding proteomic, metabolomic, and clinical aging measures to polygenic scores boosted prediction accuracy in two large human cohorts.Adding proteomic, metabolomic, and clinical aging measures to polygenic scores boosted prediction accuracy in two large human cohorts.

Cohort study of 16,215 peopleAlzheimer's disease and related dementias

Paper

Frontiers in Physiology28 Sep

Exercise-induced hypertension, leukocyte telomere length, and dietary antioxidant intake in elite male taekwondo athletes: an integrated analysis

Cross-sectional study of 108 peopleHypertension

Paper

Ageing markers

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