GPX7
- 3 independent labs in 3 countries
- Funders: Natural Science Foundation of Fujian Province and 7 more
- Animals3
- Model organisms1
Interventions
2GNF-5837
upin rats1
1 study
GNF-5837
upin rats1
GNF-5837 increases GPX7 in rats.
“GNF-5837 alleviated IVDD in rats by upregulating GPX7.”
AnimalsIVDD rat model
GNF-5837 alleviates intervertebral disc ageing by upregulating glutathione peroxidase 7
International journal of immunopathology and pharmacology6 Jun 2025
Alginate oligosaccharide
upin rats1
1 study
Alginate oligosaccharide
upin rats1
Alginate oligosaccharide increases GPX7 in rats.
“AOS upregulated the expression of glutathione peroxidase 7 (GPX7) in aging rats”
Animalsnatural aging
Alginate oligosaccharide alleviates vascular aging by upregulating glutathione peroxidase 7
The Journal of nutritional biochemistry10 Jan 2024
Effects
1Cellular senescence
downin human cells1
1 study
Cellular senescence
downin human cells1
GPX7 decreases cellular senescence in human cells.
“GPX7 overexpression reduced ageing in NP cells.”
Cellsin NP cells
GNF-5837 alleviates intervertebral disc ageing by upregulating glutathione peroxidase 7
International journal of immunopathology and pharmacology6 Jun 2025
Associations
1Carcinogenesis
downin mice1
1 study
Carcinogenesis
downin mice1
GPX7 lowers the risk of carcinogenesis in mice.
“Complete loss of NPGPx in animals causes systemic oxidative stress, increases carcinogenesis, and shortens life span.”
Animalsshown by loss of NPGPx
Molecular cell1 Nov 2012