Pieternella Eline Slagboom

Leiden University Medical Center

Also published as: P.E. Slagboom, Eline Slagboom, Eline P. Slagboom, P. Eline Slagboom, Pieternella E. Slagboom

153 papersORCID 0000-0002-2875-4723 OpenAlex

Max Planck Institute for Biology of Ageing

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Papers

BMC MedicineSep 7

Personal-MetaboHealth, an actionable health check in middle age, is improved by an effective lifestyle intervention in those at risk

Cohort study of 2,404 peopleBiomarkers

bioRxivMay 28

Rare genetic variants in the IIS/mTOR signalling pathway identified in exceptionally long-lived individuals show shared in vitro effects associated with lifespan across species

Preprint: experiments in mouse cellsmTOR signaling

Nature MetabolismMay 15

Human whole-blood NAD⁺ levels do not vary with age or lifestyle interventions

Cohort study in peopleNAD+

medRxivMay 15

Multi-omics integration identifies metabolic and inflammatory pathways underlying familial longevity

Preprint: cross-sectional study of 495 peopleAmino acid metabolism

GeroScienceMay 1

Low genetic risk for coronary artery disease underlies multigenerational longevity and healthy aging

Cohort study in peopleCoronary artery disease

Atherosclerosis PlusApr 20

Associations of NMR metabolic biomarkers and arterial calcification: An observational and Mendelian randomization study within the BBMRI metabolomics consortium

Cohort study of 271,793 peopleCoronary artery calcification

Cell Reports MethodsApr 12

ProtFI, an efficient frailty-trained proteomics-based biomarker of aging, robustly predicts age-related decline

Cohort study of 40,696 peopleBiomarkers

Aging CellMar 13

Biologically Younger Individuals, as Identified by MARK-AGE Biological Age Scores, Display a Distinct Favourable Blood Chemistry Profile Regardless of Age

Cohort study of 3,300 peopleBiomarkers

Journal of Cachexia, Sarcopenia and MuscleMar 9

Effects of a Combined Dietary and Physical Activity Intervention on Bone Density, Lean Mass and Fat Mass in Adults: The GOTO Trial

Non-randomized trial in 134 peopleBones and joints

medRxivFeb 9

The plasma proteins GSN, F2, CRTAC1, and HP reflect multigenerational health, longevity, and resilience

Preprint: cohort study of 2,282 peopleBiomarkers

ObesityJan 15

The MetaboHealth Score Enhances Insulin Resistance Metabotyping for Targeted Fat Loss: The PERSON Study

Trial in peopleInterventions

AAIC 2025 AbstractDec 25

Integrative cross‐omics analysis identifies DNA methylation signatures associated with bilateral hippocampal volume, asymmetry and atrophy rate in the general population

Cohort study of 8,156 peopleBiomarkers

bioRxivDec 22

Rare longevity-associated variants, including a reduced-function mutation in cGAS, identified in multigenerational long-lived families

Preprint: genetic association study of 212 peopleCGAS

Nederlands Tijdschrift Voor GeneeskundeNov 19

Molecular biomarkers of biological age; how we can use them, now and in the future

ReviewBiomarkers

Journal of Healthcare Informatics ResearchNov 13

Multi-Cohort Federated Learning Shows Synergy in Mortality Prediction for MRI-Based and Metabolomics-Based Age Scores

Cohort study in peopleBiomarkers

Journal of Medical VirologyOct 23

TTV Species Diversity as a Novel Biomarker of Immune Dysregulation in Aging

Cohort study in peopleBiomarkers

medRxivOct 9

Blood Proteomic Biomarkers indicate reduced system and tissue level inflammation responses to The GOTO Lifestyle Intervention in Older Adults

Preprint: non-randomized trial in peopleLifestyle intervention

Immunity & AgeingSep 10

Extreme MetaboHealth scores in three cohort studies associate with plasma protein markers for inflammation and cholesterol transport

Cohort study in peopleBiomarkers

AntioxidantsAug 30

Causal Inference Approaches Reveal Associations Between LDL Oxidation, NO Metabolism, Telomere Length and DNA Integrity Within the MARK-AGE Study

Cross-sectional study of 1,326 peopleTelomerase and telomere maintenance

Journal of Nutritional ScienceAug 21

A healthful plant-based diet is associated with higher health-related quality of life among older adults independent of circulating CRP: a cross-sectional analysis from the Lifelines Cohort Study

Cross-sectional study of 6,635 peoplePopulations

BiogerontologyJul 30

Cytomegalovirus (CMV), oxidative stress, and inflammation: implications for immunosenescence and age-related diseases in the MARK-AGE population

Cross-sectional study of 2,065 peopleOxidative stress and ROS signaling

JID InnovationsJul 21

MC1R and IRF4 Gene Variants Are Associated with p16INK4a-Positive Epidermal Cells

Cohort study of 166 peopleCDKN2A

GeroScienceMay 30

Functional characterisation of rare variants in genes encoding the MAPK/ERK signalling pathway identified in long-lived Leiden Longevity Study participants

Study in peopleMAPK/ERK signaling

GeroScienceApr 15

German longevity study reveals novel rare pro-longevity alleles clustering in mTOR signaling pathway

Genetic association study of 4,105 peoplemTOR signaling

GeroScienceMar 12

Associations between metabolomic scores and clinical outcomes in hospitalized COVID-19 patients

Cohort study of 346 peopleCOVID-19

Mechanisms of Ageing and DevelopmentMar 3

Association of cytomegalovirus serostatus with ELOVL2 methylation: Implications for lipid metabolism, inflammation, DNA damage, and repair capacity in the MARK-AGE study population

Cohort study in peopleBiomarkers

BMC NeurologyFeb 13

Identifying pathways to the prevention of dementia: the Netherlands consortium of dementia cohorts

Cohort study of 2,554 peopleAI & data

The Journal of Nutrition, Health & AgingDec 22

Unhealthful plant-based diet associates with frailty risk predominantly in men with low income from the UK Biobank cohort

Cross-sectional study of 73,180 peoplePopulations

medRxivDec 20

The MetaboHealth score enhances insulin resistance metabotyping for targeted fat loss through personalized diets: Insights from the PERSON intervention study

Preprint: randomized trial in 242 peopleInsulin resistance

NeuroendocrinologyDec 4

Effect of Thyroid Status Modulation on Pituitary and Peripheral Hormone Concentrations in Healthy Older Subjects

Non-randomized trial in 29 peopleMechanisms

Aging CellDec 2

Tissue-specific methylomic responses to a lifestyle intervention in older adults associate with metabolic and physiological health improvements

Non-randomized trial in peopleInterventions

medRxivDec 2

Extreme MetaboHealth scores in three cohort studies associate with plasma protein markers for inflammation and cholesterol transport

Preprint: cross-sectional study of 726 peopleBiomarkers

Age and AgeingNov 19

Association between metabolomics-based biomarker scores and 10-year cognitive decline in men and women. The Doetinchem Cohort Study

Cohort study of 2,821 peopleBiomarkers

Mechanisms of Ageing and DevelopmentNov 4

Design of the VOILA-intervention study: A 12-week nutrition and resistance exercise intervention in metabolic or mobility compromised Dutch older adults and the response on immune-metabolic, gut and muscle health parameters

Study protocolResistance training

The Journals of Gerontology, Series AOct 25

Association Between TTV Viremia, Chronic Inflammation, and Ischemic Heart Disease Risk: Insights From MARK-AGE and Report-Age Projects

Cross-sectional study in peopleIschemic heart disease

GeroScienceOct 22

Increased ¹H-NMR metabolomics-based health score associates with declined cognitive performance and functional independence in older adults at risk of cardiovascular disease

Cohort study of 5,292 peopleBiomarkers

Journal of Geriatric OncologyOct 17

Association of Glasgow Prognostic Score with frailty, mortality and adverse health outcomes in older patients with cancer: A prospective cohort study

Cohort study of 192 peopleCancer

Advanced ScienceSep 27

A Novel Metabolomic Aging Clock Predicting Health Outcomes and Its Genetic and Modifiable Factors

Cohort study of 239,291 peopleBiomarkers

Nature AgingSep 17

Challenges and recommendations for the translation of biomarkers of aging

Study in peopleBiomarkers

Mechanisms of Ageing and DevelopmentSep 17

Development and validation of cardiometabolic risk predictive models based on LDL oxidation and candidate geromarkers from the MARK-AGE data

Cross-sectional study of 1,089 peopleCardiometabolic risk

arXivSep 2

MRI-based and metabolomics-based age scores act synergetically for mortality prediction shown by multi-cohort federated learning

Preprint: computational studyBiomarkers

Nature CommunicationsAug 16

Secondary integrated analysis of multi-tissue transcriptomic responses to a combined lifestyle intervention in older adults from the GOTO nonrandomized trial

Non-randomized trial in peopleInterventions

iScienceJul 18

Association between bilirubin and biomarkers of metabolic health and oxidative stress in the MARK-AGE cohort

Cohort study of 2,489 peopleBiomarkers

Reproductive Biomedicine OnlineJul 5

Late reproduction is associated with extended female survival but not with familial longevity

Cohort study of 10,255 peoplePopulations

GeroScienceJul 4

The performance of metabolomics-based prediction scores for mortality in older patients with solid tumors

Cohort study of 192 peopleBiomarkers

Experimental GerontologyMay 31

Physical activity and fiber intake beneficial for muscle mass and strength preservation during aging: A comprehensive cross-sectional study in the UK biobank cohort

Cross-sectional study of 45,984 peopleMuscle

Alzheimer's Research & TherapyMay 21

Plasma trimethylamine N-oxide (TMAO): associations with cognition, neuroimaging, and dementia

Cohort study of 3,143 peopleTrimethylamine N-oxide

medRxivApr 22

Heterogeneous metabolomic aging across the same age and prediction of health outcome

Preprint: cohort study of 239,291 peopleBiomarkers

European Journal of EpidemiologyApr 6

The AccelerAge framework: a new statistical approach to predict biological age based on time-to-event data

Computational studyBiological age

BMC Medical Research MethodologyMar 9

Clarifying the biological and statistical assumptions of cross-sectional biological age predictors: an elaborate illustration using synthetic and real data

Computational studyBiological age

Nature MedicineFeb 15

Validation of biomarkers of aging

ReviewBiomarkers

medRxivNov 30

A healthful plant-based diet is associated with higher physical and mental well-being among older adults independent of circulating CRP

Preprint: cohort study of 6,635 peoplePopulations

medRxivNov 27

Changes in the physical behaviour of older adults during the 13 weeks GOTO intervention explain a boost in immuno-metabolic health

Preprint: study in peopleInterventions

GeroScienceNov 14

Identified senescence endotypes in aged cartilage are reflected in the blood metabolome

Cohort study of 57 peopleBiomarkers

GeroScienceSep 16

Associations of circulating GDF15 with combined cognitive frailty and depression in older adults of the MARK-AGE study

Cross-sectional study of 2,736 peopleGDF-15

medRxivAug 8

Transcriptomic Response of Postprandial Blood, Subcutaneous Adipose Tissue and Muscle to a combined lifestyle intervention in older adults

Preprint: non-randomized trial in peopleMuscle

Nature CommunicationsJul 28

Increasing number of long-lived ancestors marks a decade of healthspan extension and healthier metabolomics profiles

Cohort study of 17,539 peoplePopulations

NutrientsJul 11

Uncovering the Relationship between Selenium Status, Age, Health, and Dietary Habits: Insights from a Large Population Study including Nonagenarian Offspring from the MARK-AGE Project

Cross-sectional study of 2,200 peoplePopulations

medRxivJun 28

Late reproduction is associated with extended female survival but not with familial longevity

Preprint: cohort study of 10,255 peoplePopulations

The Journals of Gerontology, Series AJun 12

Epigenetic and Metabolomic Biomarkers for Biological Age: A Comparative Analysis of Mortality and Frailty Risk

Cohort study of 3,222 peopleBiomarkers

bioRxivJun 1

Functional characterisation of rare variants in genes encoding the MAPK/ERK signalling pathway identified in long-lived Leiden Longevity Study participants

Preprint: study in peopleMAPK/ERK signaling

Diagnostic and Prognostic ResearchApr 5

A study protocol of external validation of eight COVID-19 prognostic models for predicting mortality risk in older populations in a hospital, primary care, and nursing home setting

European Journal of NutritionDec 27

Pooled analysis of epigenome-wide association studies of food consumption in KORA, TwinsUK and LLS

Study of 2,293 peoplePopulations

GerontologyDec 21

Association of Torquetenovirus Viremia with Physical Frailty and Cognitive Impairment in Three Independent European Cohorts

Cohort study in peopleCognitive impairment

FASEB JournalOct 3

PLIS: A metabolomic response monitor to a lifestyle intervention study in older adults

Study in peopleBiomarkers

SleepOct 3

Gut microbiome changes due to sleep disruption in older and younger individuals: a case for sarcopenia?

Systematic review of studies in peopleMicrobiome composition

bioRxivSep 8

Increasing number of long-lived ancestors associates with up to a decade of healthspan extension and a healthy metabolomic profile in mid-life

Preprint: cohort study of 17,539 peoplePopulations

AgingAug 19

The association between continuous ambulatory heart rate, heart rate variability, and 24-h rhythms of heart rate with familial longevity and aging

Cross-sectional study in peopleHeart rate variability

The Journals of Gerontology, Series AAug 2

Bacterial DNAemia in Older Participants and Nonagenarian Offspring and Association With Redox Biomarkers: Results From MARK-AGE Study

Cross-sectional study in peopleMechanisms

GeroScienceJul 22

Circulating cell-free DNA in health and disease - the relationship to health behaviours, ageing phenotypes and metabolomics

Cohort study of 5,385 peopleBiomarkers

Genome BiologyJan 16

Functional genomics analysis identifies T and NK cell activation as a driver of epigenetic clock progression

Cohort study of 3,132 peopleMechanisms

Human Molecular GeneticsDec 8

Fat metabolism is associated with telomere length in six population-based studies

Study of 11,775 peopleTelomere length

International Journal of ObesityNov 17

Timing of objectively-collected physical activity in relation to body weight and metabolic health in sedentary older people: a cross-sectional and prospective analysis

Cohort study of 207 peoplePopulations

International Journal of Molecular SciencesSep 29

Functional Changes of T-Cell Subsets with Age and CMV Infection

Cohort study in peopleBlood and immune system

JAMA Internal MedicineSep 8

Association of Thyroid Dysfunction With Cognitive Function: An Individual Participant Data Analysis

Study of 74,565 peopleThyroid disease

Nature Human BehaviourJul 3

Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour

Study in peoplePopulations

The Journals of Gerontology, Series AMay 14

Age, Sex, and BMI Influence on Copper, Zinc, and Their Major Serum Carrier Proteins in a Large European Population Including Nonagenarian Offspring From MARK-AGE Study

Cross-sectional study of 2,424 peopleBiomarkers

GeroScienceApr 20

Ageing affects subtelomeric DNA methylation in blood cells from a large European population enrolled in the MARK-AGE study

Cross-sectional study of 2,000 peopleBiomarkers

BMC GenomicsMar 17

Correction for both common and rare cell types in blood is important to identify genes that correlate with age

Study in peopleMechanisms

BMC Medical Research MethodologyJan 8

Improved selection of participants in genetic longevity studies: family scores revisited

Computational studyBiomarkers

Circulation Genomic and Precision MedicineOct 21

Metabolic Age Based on the BBMRI-NL ¹H-NMR Metabolomics Repository as Biomarker of Age-related Disease

Cohort study of 25,000 peopleBiomarkers

The Journal of Infectious DiseasesSep 11

Associations of Cytomegalovirus Infection With All-Cause and Cardiovascular Mortality in Multiple Observational Cohort Studies of Older Adults

Study in peoplePopulations

bioRxivMay 30

Correction for both common and rare cell types in blood is important to identify genes that correlate with age

Preprint: computational studyMechanisms

Aging CellMay 1

Longevity Relatives Count score identifies heritable longevity carriers and suggests case improvement in genetic studies

Genetic association study of 37,825 peoplePopulations

Molecular Nutrition & Food ResearchApr 10

Lifestyle-Intervention-Induced Reduction of Abdominal Fat Is Reflected by a Decreased Circulating Glycerol Level and an Increased HDL Diameter

Trial in peopleInterventions

FASEB JournalMar 5

A data-driven methodology reveals novel myofiber clusters in older human muscles

Study in peopleAI & data

MetabolomicsMar 4

Metabolomics analyses in non-diabetic middle-aged individuals reveal metabolites impacting early glucose disturbances and insulin sensitivity

Study in peopleBiomarkers

American Journal of Human GeneticsFeb 29

Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length

Genetic association study of 350,000 peopleTelomere length

The Journal of Clinical Endocrinology and MetabolismDec 20

Interrelationships Between Pituitary Hormones as Assessed From 24-hour Serum Concentrations in Healthy Older Subjects

Study in peopleMechanisms

The Journals of Gerontology, Series ADec 16

Prevalence and Loads of Torquetenovirus in the European MARK-AGE Study Population

Study in peopleBiomarkers

NutrientsDec 11

Nutritional Factors Modulating Alu Methylation in an Italian Sample from The Mark-Age Study Including Offspring of Healthy Nonagenarians

Study in peopleBiomarkers

Scientific ReportsDec 10

WGS-based telomere length analysis in Dutch family trios implicates stronger maternal inheritance and a role for RRM1 gene

Study in peopleBiomarkers

The EMBO JournalOct 22

Senescent human melanocytes drive skin ageing via paracrine telomere dysfunction

Experiments in human cellsTelomerase and telomere maintenance

bioRxivOct 1

Dynamic Clonal Hematopoiesis and Functional T-cell Immunity in a Super-centenarian

Preprint: study in peopleMechanisms

Journal of the European Academy of Dermatology and VenereologyAug 17

Basal cell carcinoma genetic susceptibility increases the rate of skin ageing: a Mendelian randomization study

Study in peopleMechanisms

Nature CommunicationsAug 16

A meta-analysis of genome-wide association studies identifies multiple longevity genes

Study of 25,483 peoplePopulations

Scientific ReportsAug 14

Metabolomics reveals a link between homocysteine and lipid metabolism and leukocyte telomere length: the ENGAGE consortium

Study in peopleBiomarkers

Acta NeuropathologicaMay 28

A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

Genetic association study of 149,290 peopleDementia with Lewy bodies

bioRxivMay 3

Genome-wide association study of plasma triglycerides, phospholipids and relation to cardio-metabolic risk factors

Preprint: study in peopleBiomarkers

MetabolomicsMar 5

Metabolomic and lipidomic assessment of the metabolic syndrome in Dutch middle-aged individuals reveals novel biological signatures separating health and disease

Study in peopleBiomarkers

Works at

Max Planck Institute for Biology of Ageing
Leids Universitair Medisch Centrum
Lead investigator

Sources: doi.org, openalex.org

Grants and prizes

ZonMw
["ZonMw Open Competitie"], Socio-genetic mechanisms underlying familial longevity and the protection from (multi)morbidity, zonmw-09120012010052-36777, 2021–2026, Oct 1, 2021

Sources: openalex.org

Earlier work