Leids Universitair Medisch Centrum

• Niels Berg

  Lead investigator

• Ton Rabelink

  Lead investigator

• dr. S.P. Jochems

  Lead investigator

• dr. S.F.A. Askar MD PhD

  Lead investigator

• P. Eline Slagboom

  Lead investigator

• Hanneke Kort

  Lead investigator

• Simon Jochems

  Lead investigator

• Ingrid Meulenbelt

  Lead investigator

• E.B. van den Akker

  Lead investigator

• dr. mr. Y.M. Drewes

  Lead investigator

• Dr. R.K.E. Poortvliet

  Lead investigator

• Dr. D.C.F. Salvatori PhD

  Lead investigator

• Dr. S.P. Mooijaart MD PhD

  Lead investigator

• Prof. dr. R.A.E.M. Tollenaar

  Lead investigator

• dr. M.A.A. Caljouw PhD

  Lead investigator

Sources: openalex.org

• Managing Pasireotide-associated Hyperglycaemia in Acromegaly With Ketogenic Diet

  Recruiting, 30 people, Oct 8, 2026

• NCT07816978

  Collaborator, Phase 4, Not yet recruiting, 400 people, Sep 14, 2026

• NCT07535762

  Collaborator, Phase 2, Not yet recruiting, 36 people, Apr 17, 2026

• NCT07535710

  Collaborator, Phase 1/2, Not yet recruiting, 37 people, Apr 17, 2026

• NCT07486726

  Collaborator, Phase 1/2, Not yet recruiting, 112 people, Mar 20, 2026

• NCT07090343

  Phase 3, Not yet recruiting, 826 people, Jul 29, 2025

• NCT06888817

  Collaborator, Phase 3, Recruiting, 408 people, Mar 21, 2025

• MethMax Trial: MAXimising the METHotrexate Therapy Potential in Patients With Active Rheumatoid Arthritis

  Collaborator, Phase 4, Recruiting, 182 people, Oct 18, 2024

• NCT06394999

  Phase 3, Active, not recruiting, 615 people, May 1, 2024

• NCT06101745

  Collaborator, Phase 2/3, Recruiting, 336 people, Oct 26, 2023

• NCT06079333

  Phase 2, Recruiting, 20 people, Oct 12, 2023

• NCT05924685

  Collaborator, Phase 4, Completed, 110 people, Jun 29, 2023

• NCT05725512

  Phase 4, Recruiting, 490 people, Feb 13, 2023

• NCT05680389

  Phase 1/2, Status unknown, 60 people, Jan 11, 2023

• NCT05468606

  Early phase 1, Status unknown, 45 people, Jul 21, 2022

• NCT05456932

  Phase 4, Status unknown, 90 people, Jul 13, 2022

• NCT05324748

  Phase 3, Recruiting, 50 people, Apr 12, 2022

• Refining Adjuvant Treatment IN Endometrial Cancer Based On Molecular Features

  Phase 3, Recruiting, 316 people, Feb 24, 2022

• NCT05221411

  Phase 4, Status unknown, 86 people, Feb 3, 2022

• NCT05077085

  Phase 4, Withdrawn, 0 people, Oct 13, 2021

Sources: clinicaltrials.gov

• Nederlandse Organisatie voor Wetenschappelijk Onderzoek

  NWO-Talentprogramma Veni SGW 2024 - Sociale Wetenschappen, Spousal survival Advantage by Marrying into Longevity Enriched families (SAME), VI.Veni.241S.034, 2026, Jan 5, 2026

• Nederlandse Organisatie voor Wetenschappelijk Onderzoek

  NWA L3 - Vernieuwing - Innovatieve projecten in routes 2024, Exploring the future of regenerative medicine in the Netherlands, NWA.1418.24.056, 2025, Apr 1, 2025

• ZonMw

  ["Vidi"], VACCINAGE: understanding reduced vaccine responses in older adults, zonmw-09150172210056-41343, 2023–2028, Sep 1, 2023

• ZonMw

  ["Off Road"], Xenotransformation: Regeneration Through Non-Human to Human Cellular Transdifferentiation, zonmw-04510012110022-37019, 2023, Jan 1, 2023

• ZonMw

  ["ZonMw Open Competitie"], Socio-genetic mechanisms underlying familial longevity and the protection from (multi)morbidity, zonmw-09120012010052-36777, 2021–2026, Oct 1, 2021

• Nederlandse Organisatie voor Wetenschappelijk Onderzoek

  NWA L3 - Vernieuwing - Kleine projecten NWA-routes, Regenerative Medicine: three small projects on route for knowledge utilisation, NWA.1418.20.015, 2021–2023, Jun 1, 2021

• Nederlandse Organisatie voor Wetenschappelijk Onderzoek

  Open Competitie ENW - M Doorlopend OC ENW KLEIN Pakket 08, Changes in nasal mucosal T cells associated with susceptibility to respiratory infections during aging, OCENW.KLEIN.461, 2021–2024, May 1, 2021

• Nederlandse Organisatie voor Wetenschappelijk Onderzoek

  Open Competitie ENW XL (voorheen OC ENW-GROOT) Ronde 2019, Single Cell Microgel embedded iPS-cells to map molecular variability of cell differentiation using a systems biology approach (SCI-MAP), OCENW.GROOT.2019.079, 2021, Jan 1, 2021

• ZonMw

  Talentontwikkeling en vrij onderzoek, Age-related clonal hematopoiesis: the good and the bad of clonally expanding immune subsets, zonmw-09150161810095-36681, 2020, Jan 1, 2020

• ZonMw

  ["Huisartsgeneeskunde en Ouderengeneeskunde"], GR-HIP: Geriatric Rehabilitation of patients after HIP fracture; functioning and burden of patients and primary caregivers after hip fracture., zonmw-839120010-23587, 2017–2023, Dec 1, 2017

• ZonMw

  ["Memorabel"], Effects of stopping antihypertensive treatment on neuropsychiatric symptoms in nursing home residents with dementia, zonmw-733050835-23816, 2017–2022, Dec 1, 2017

• ZonMw

  ["Meer Kennis met Minder Dieren"], Substitution of the mouse tumorigenicity assay with a complete in vitro microRNA based assay for testing malignancy of human induced pluripotent stem cells, zonmw-114021504-24266, 2017–2022, Jun 1, 2017

• ZonMw

  ["Evidence based Medicine in Old Age", "Goed Gebruik Geneesmiddelen"], Implementation of a screening program for older adults visiting the Emergency Department; a feasibility study, zonmw-627005001-24072, 2017–2018, Feb 1, 2017

• ZonMw

  ["Preventie 5: Deelprogramma 5 - Vroege opsporing"], Early detection of sporadic and hereditary pancreatic cancer using serum protein profiling., zonmw-531002011-19395, 2016–2021, Nov 1, 2016

• ZonMw

  ["Huisartsgeneeskunde en Ouderengeneeskunde"], Paracetamol to enhance quality of life and daily function and to decrease care dependency in advanced dementia: A randomized, double-blind, placebo-controlled crossover trial in long-term care facilities., zonmw-839120006-21325, 2016–2022, Mar 1, 2016

Sources: openalex.org

• Depressive symptom profiles and risk of cardiometabolic disease incidence

  Oct 2, 2026

• Recommendations for the management of frailty in chronic kidney disease: a consensus report

  Sep 25, 2026

• Age-associated B cells predict coronary events in humans and aggravate murine atherosclerosis

  Sep 24, 2026

• Frailty of older patients is not reflected in the melanoma tumor microenvironment and treatment response to immune checkpoint blockade therapy

  Sep 18, 2026

• Six-year trajectories of cognitive, physical and social functioning in adults with late-life depression

  Sep 9, 2026

• Ageing of the Upper Airway Epithelial Niche Limits Tissue-Resident T Cell Immunity

  Jul 16, 2026

• The Association Between Relocations and Health Outcomes in Nursing Home Residents: A Retrospective Cohort Study

  Jul 3, 2026

• Low genetic risk for coronary artery disease underlies multigenerational longevity and healthy aging

  May 1, 2026

• Biologically Younger Individuals, as Identified by MARK-AGE Biological Age Scores, Display a Distinct Favourable Blood Chemistry Profile Regardless of Age

  Mar 1, 2026

• Impact of geriatric impairments on outcomes of single-agent immunotherapy in solid tumors

  Oct 4, 2025

• Clinical Frailty Scale, Surprise Question and 1-year Mortality in Older Patients with Advanced CKD

  Aug 21, 2025

• Effects of the discontinuation of antihyper-tensive treatment on neuropsychiatric symptoms and quality of life in nursing home residents with dementia (DANTON). A multicentre, open-label, blinded-outcome, randomised controlled trial

  Jun 10, 2025

• Impact of immune-related adverse events on quality of life and physical functioning in older patients with solid tumors treated with immune checkpoint inhibitors

  Jun 7, 2025

• Dermal cellular senescence and EndMT in patients with systemic sclerosis undergoing cyclophosphamide or aHSCT treatment

  Jun 1, 2025

• A fasting-mimicking diet programme reduces abdominal adipose tissue while preserving abdominal muscle mass in persons with type 2 diabetes

  Apr 30, 2025

• Lifestyle behaviours do not moderate the association between childhood maltreatment and comorbid depression and cardiometabolic disease in older adults: a meta-analysis

  Mar 5, 2025

• A fasting-mimicking diet programme reduces liver fat and liver inflammation/fibrosis measured by magnetic resonance imaging in patients with type 2 diabetes

  Feb 18, 2025

• Development of Reliable and High-Throughput Human Biomimetic Cartilage and Bone Models to Explore Senescence and Personalized Osteoarthritis Treatment Options

  Feb 17, 2025

• Endothelial dysfunction in the aging kidney

  Feb 11, 2025

• Robust Metabolomic Age Prediction Based on a Wide Selection of Metabolites

  Feb 10, 2025

Sources: openalex.org, api.crossref.org

• Carriers of the p.P522R variant in PLCγ2 have a slightly more responsive immune system

  Consulting or advice, Fees or honoraria, Apr 20, 2023

Sources: pubmed.ncbi.nlm.nih.gov

• COVID-19 deaths exceeded excess deaths in older Dutch people

  Statistica Neerlandica, Oct 23, 2026

• Weight loss and blood pressure lowering with GLP-1 receptor agonists and multi-hormone receptor modulators in overweight and obesity: a systematic review and meta-regression of phase 3 clinical trials

  EClinicalMedicine, Oct 22, 2026

• Glucagon-Like Peptide-1 Receptor Agonists and Multi-hormone Receptor Modulators for Kidney Protection in Nondiabetic Kidney Disease

  Journal of the American Society of Nephrology : JASN, Oct 19, 2026

• BMI as a partitioning factor for estradiol and estrone reference intervals in middle-aged men and postmenopausal women

  European journal of endocrinology, Oct 19, 2026

• No faster decline seen in women 75-plus with early breast cancer

  medRxiv, Oct 15, 2026

• Home-based geriatric rehabilitation after shortened inpatient rehabilitation: cost-effectiveness analysis of the "Better@Home" multicentre prospective cohort study with a matched historical control group

  The European journal of health economics : HEPAC : health economics in prevention and care, Oct 15, 2026

• Duodenal involvement in MUTYH-associated polyposis: findings from an international study and implications for endoscopic surveillance

  The American journal of gastroenterology, Oct 13, 2026

• Rapid progression of coronary atherosclerosis across glycemic status: a serial coronary computed tomography angiography study from the PARADIGM registry

  Cardiovascular diabetology, Oct 9, 2026

• Longer chains in lipids were linked to aging in humans

  Nature aging, Oct 7, 2026

• Late-life pain was more common where development ranked lowest

  Nature medicine, Oct 6, 2026

• The modulatory role of early-life experiences and sex on cognitive resilience in APP/PS1 mice over time

  bioRxiv, Oct 5, 2026

• Depressive symptom profiles and risk of cardiometabolic disease incidence

  Journal of affective disorders, Oct 3, 2026

• Description of the APOLLO Registry: Integrated Cardio-Renal Perfusion Assessment and Cardiometabolic Phenotyping Using Cardiac 82Rb-PET/CT

  medRxiv, Oct 2, 2026

• Blood cell composition explains substantial variation in DNA methylation age

  Genome medicine, Oct 2, 2026

• Trajectories of Cognitive Functioning in Older Age Bipolar Disorder

  Bipolar disorders, Oct 1, 2026

• Genetically proxied CETP inhibition links to higher AMD risk

  Ophthalmology, Sep 30, 2026

• Longitudinal body composition changes distinguish pancreatic ductal adenocarcinoma from controls in a pre-diagnostic CT cohort

  Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], Sep 29, 2026

• A Cardiovascular Care Pathway Supported by Remote Patient Management in Dutch Primary Care: Cost-Effectiveness, Budget Impact, and Workload Analysis

  JMIR mHealth and uHealth, Sep 29, 2026

• The impact of physical activity and exercise timing on metabolic health among individuals at high risk of type 2 diabetes

  Diabetologia, Sep 28, 2026

• Recommendations for the management of frailty in chronic kidney disease: a consensus report

  Nature reviews. Nephrology, Sep 26, 2026