There are 6 papers on aging in Aged animals: none in people yet, 1 in animals, 5 reviews.
6 papers study it8 findings
- Animals1
Interventions
4Spermidine
no changeCA3-CA1 synaptic function and morphology1downloss of neuronal mitochondria1uppresynaptic MF-CA3 long-term potentiation1upsynaptic vesicle density1
1 study
Spermidine
no changeCA3-CA1 synaptic function and morphology1downloss of neuronal mitochondria1uppresynaptic MF-CA3 long-term potentiation1upsynaptic vesicle density1
Spermidine showed no clear effect on CA3-CA1 synaptic function and morphology in A. animals (CA3-CA1 synapses in aged animals).
“spermidine failed to protect CA3-CA1 hippocampal synapses characterized by postsynaptic LTP from age-related changes in function and morphology”
AnimalsCA3-CA1 synapses in aged animalsdietaryhippocampus
Spermidine protects from age-related synaptic alterations at hippocampal mossy fiber-CA3 synapses
Scientific reports
Spermidine prevents loss of neuronal mitochondria in A. animals (aged animals).
“prevents the aging-induced loss of neuronal mitochondria”
Animalsaged animalsdietary
Spermidine protects from age-related synaptic alterations at hippocampal mossy fiber-CA3 synapses
Scientific reports
Spermidine increases presynaptic MF-CA3 long-term potentiation in A. animals (MF-CA3 synapses in aged animals).
“largely restored defective presynaptic MF-CA3 long-term potentiation (LTP) at MF-CA3 synapses”
AnimalsMF-CA3 synapses in aged animalsdietaryhippocampus
Spermidine protects from age-related synaptic alterations at hippocampal mossy fiber-CA3 synapses
Scientific reports
Spermidine increases synaptic vesicle density in A. animals (MF-CA3 synapses in aged animals).
“Dietary spermidine rescued age-dependent decreases in synaptic vesicle density”
AnimalsMF-CA3 synapses in aged animalsdietaryhippocampus
Spermidine protects from age-related synaptic alterations at hippocampal mossy fiber-CA3 synapses
Scientific reports
Ethanol
upbehavioral effects1upethanol-induced ataxia1
1 study
Ethanol
upbehavioral effects1upethanol-induced ataxia1
Ethanol increases ethanol-induced ataxia in A. animals (compared with younger animals).
“greater effects on ethanol-induced ataxia, cognition and sleep time”
Reviewcompared with younger animals
I can't drink what I used to: The interaction between ethanol and the aging brain
International review of neurobiology
Ethanol increases behavioral effects in A. animals (compared with younger animals).
“ethanol exposure produces significantly greater effects in aged animals compared to younger animals on many, if not all, behavioral tasks”
Reviewcompared with younger animals
I can't drink what I used to: The interaction between ethanol and the aging brain
International review of neurobiology
Caloric restriction
upmuscle quality1
1 study
Caloric restriction
upmuscle quality1
Caloric restriction improves muscle quality in aged animals.
“Pharmaceutical inhibition of mTORC1 as well as caloric restriction significantly improves muscle quality in aged animals”
Reviewin aged animalsskeletal muscle
Cells
mTORC1 inhibitors
upmuscle quality1
1 study
mTORC1 inhibitors
upmuscle quality1
mTORC1 inhibitors improve muscle quality in aged animals.
“Pharmaceutical inhibition of mTORC1 as well as caloric restriction significantly improves muscle quality in aged animals”
Reviewin aged animalsskeletal muscle
Cells