mTORC1 inhibitors

1. mTORC1 inhibitors improve muscle quality in aged animals.

   “Pharmaceutical inhibition of mTORC1 as well as caloric restriction significantly improves muscle quality in aged animals”

   Reviewin aged animalsskeletal muscle

   Age-Related Dysfunction in Proteostasis and Cellular Quality Control in the Development of Sarcopenia

   Cells·Jan 7, 2023

1. mTORC1 inhibitors decrease metabolic defects in RagAGTP mice.

   “and revert by pharmacological inhibition of mTORC1”

   Animalsin RagAGTP mice

   Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling

   Nature communications·Jun 16, 2021

1. mTORC1 inhibitors decrease glomerulosclerosis in Ercc1-deficient mice.

   “Moreover, pharmacological inhibition of mTORC1 modulated the development of glomerulosclerosis in Ercc1 -deficient mice.”

   Animalsin Ercc1-deficient micekidney

   Loss of genome maintenance accelerates podocyte damage and aging

   bioRxiv (Cold Spring Harbor Laboratory)·Sep 13, 2020Preprint

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1. mTORC1 inhibitors protect against extracellular matrix catabolism in human cells (inflammation-induced).

   “protect against inflammation-induced apoptosis, senescence, and matrix catabolism in human disc cells”

   Cellsinflammation-inducednucleus pulposus cells

   Pharmacological inhibition of mTORC1 but not mTORC2 protects against human disc cellular apoptosis, senescence, and extracellular matrix catabolism through Akt and autophagy induction

   Osteoarthritis and cartilage·Feb 1, 2019

1. mTORC1 inhibitors activate autophagy in human cells.

   “promoted autophagy with light chain 3 (LC3)-II increases and p62/sequestosome 1 (p62/SQSTM1) decreases”

   Cellsnucleus pulposus cells

   Pharmacological inhibition of mTORC1 but not mTORC2 protects against human disc cellular apoptosis, senescence, and extracellular matrix catabolism through Akt and autophagy induction

   Osteoarthritis and cartilage·Feb 1, 2019

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