Human genetics

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HGG AdvancesIn silico2 Oct

Summary-level genetic method improves Alzheimer's risk prediction

The endoPRS-SS framework boosted computational efficiency up to 90-fold while using summary statistics and multiple endophenotypes to improve…The endoPRS-SS framework boosted computational efficiency up to 90-fold while using summary statistics and multiple endophenotypes to improve Alzheimer's disease risk prediction.

medRxivIn silicoPreprint2 Oct

Alzheimer's polygenic risk scores vary widely across models

Across 1,752 models, correlations ranged from -0.49 to 1, with more than 95% of individuals placing in both the top and bottom risk deciles.Across 1,752 models, correlations ranged from -0.49 to 1, with more than 95% of individuals placing in both the top and bottom risk deciles.

Genetics in Medicine OpenHumans2 Oct

Population-specific optimization of polygenic risk scores for breast cancer in East Asians

Experimental GerontologyHumans2 Oct

Centenarians and oldest olds in Liguria - COOL: A multidisciplinary cohort study to investigate the genetic determinants of cognitive well-being in Genoa, Italy. Rationale, study protocol and baseline cohort profile

Frontiers in BioinformaticsHumans26 Sep

Human genetics

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