Ubiquinone

1. Ubiquinone has no effect on oxidative stress and ROS signalling in mice.

   “we find that UQ does not act as antioxidant in vivo”

   Animalsin vivo

   Mitochondrial function and lifespan of mice with controlled ubiquinone biosynthesis

   Nature communications·6 Mar 2015

More on Oxidative stress and ROS signalling

1. Ubiquinone decreases oxidative phosphorylation in mice.

   “Global loss of UQ leads to gradual loss of mitochondrial function”

   Animalsglobal loss of UQ

   Mitochondrial function and lifespan of mice with controlled ubiquinone biosynthesis

   Nature communications·6 Mar 2015

More on Oxidative phosphorylation

1. Ubiquinone shortens lifespan in mice.

   “Global loss of UQ leads to gradual loss of mitochondrial function, gradual development of disease phenotypes and shortened lifespan.”

   Animalsglobal loss of UQ

   Mitochondrial function and lifespan of mice with controlled ubiquinone biosynthesis

   Nature communications·6 Mar 2015

1. Ubiquinone improves mitochondrial function in mice.

   “Dietary-supplemented UQ(10) was actively incorporated in both mitochondrial membranes, and this was sufficient to reverse mutant mitochondrial phenotypes.”

   AnimalsMclk1(+/-) micemitochondria

   The submitochondrial distribution of ubiquinone affects respiration in long-lived Mclk1+/- mice

   The Journal of cell biology·8 Oct 2012

1. Ubiquinone improves development in worms.

   “Provision of Q-replete E. coli rescues these defects.”

   Model organismsin clk-1 mutants

   A dietary source of coenzyme Q is essential for growth of long-lived Caenorhabditis elegans clk-1 mutants

   Proceedings of the National Academy of Sciences of the United States of America·2 Jan 2001