COQ7

1. COQ7 decreases rate of development of oxidative biomarkers of aging in mice.

   “significant attenuation of the rate of development of oxidative biomarkers of aging”

   Animalsin aging Mclk1(+/-) mice

   Reversal of the mitochondrial phenotype and slow development of oxidative biomarkers of aging in long-lived Mclk1+/- mice

   The Journal of biological chemistry·28 May 2009

More on Rate of development of oxidative biomarkers of aging

1. COQ7 decreases plasma isoprostanes in mice.

   “decrease in oxidative damage to cytosolic proteins as well as by a decrease in plasma isoprostanes”

   AnimalsMclk1(+/-) heterozygosity

   Early mitochondrial dysfunction in long-lived Mclk1+/- mice

   The Journal of biological chemistry·17 Jul 2008

More on Plasma isoprostanes

1. COQ7 decreases ATP synthesis in mice.

   “phenotype of young Mclk1(+/-) mutants includes a severe reduction of mitochondrial electron transport, ATP synthesis, and total nicotinamide adenine dinucleotide (NAD(tot)) pool size”

   AnimalsMclk1(+/-) heterozygosity

   Early mitochondrial dysfunction in long-lived Mclk1+/- mice

   The Journal of biological chemistry·17 Jul 2008

1. COQ7 decreases mitochondrial electron transport in mice.

   “phenotype of young Mclk1(+/-) mutants includes a severe reduction of mitochondrial electron transport, ATP synthesis, and total nicotinamide adenine dinucleotide (NAD(tot)) pool size”

   AnimalsMclk1(+/-) heterozygosity

   Early mitochondrial dysfunction in long-lived Mclk1+/- mice

   The Journal of biological chemistry·17 Jul 2008

1. COQ7 decreases lifespan in worms.

   “transgenic expression reverted the extended life span of clk-1 to the comparable level with wild-type control.”

   Model organismsin clk-1 longevity mutant

   Mouse coq7/clk-1 orthologue rescued slowed rhythmic behavior and extended life span of clk-1 longevity mutant in Caenorhabditis elegans

   Biochemical and biophysical research communications·24 Aug 2001

1. COQ7 decreases slowed rhythmic behaviors in worms.

   “Transgenic expression of mouse coq7 completely rescued the slowed rhythmic behaviors of clk-1 such as defecation.”

   Model organismsin clk-1 mutant

   Mouse coq7/clk-1 orthologue rescued slowed rhythmic behavior and extended life span of clk-1 longevity mutant in Caenorhabditis elegans

   Biochemical and biophysical research communications·24 Aug 2001