Polyamines

5 papers7 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funders: National Institute of Diabetes and Digestive and Kidney Diseases and others
1 of 1 finding with company ties

Animals1

Outcomes

6

Autophagy

upin reviews2

2 studies

Polyamines activate autophagy.
“polyamines exert protective effects by promoting epithelial repair, modulating macrophage and T-cell responses, and enhancing autophagy-mediated tissue renewal and longevity.”
Review
Polyamines as a Universal Language of Host-Microbiota Symbiosis
Research (Washington, D.C.)6 Mar 2026
Polyamines activate autophagy.
“Polyamines, including putrescine, spermidine, and spermine, are vital microbial-host metabolites that support intestinal cell growth, autophagy, immune modulation, and mucosal repair.”
Review
The Diet-Microbiota-Polyamine Axis in Intestinal Aging: Microbial Pathways, Functional Foods, and Physiological Implications
Nutrients10 Feb 2026

More on Autophagy

Inflammation

downin reviews1

1 study

Polyamines protect against inflammation.
“Disruption of this host-microbiota axis reduces polyamine availability, impairs barrier function, and exacerbates inflammation.”
Review
Polyamines as a Universal Language of Host-Microbiota Symbiosis
Research (Washington, D.C.)6 Mar 2026

More on Inflammation

Lifespan

upin reviews1

1 study

Polyamines extend lifespan.
“polyamines exert protective effects by promoting epithelial repair, modulating macrophage and T-cell responses, and enhancing autophagy-mediated tissue renewal and longevity.”
Review
Polyamines as a Universal Language of Host-Microbiota Symbiosis
Research (Washington, D.C.)6 Mar 2026

Bone disease

downin reviews1

1 study

Polyamines protect against bone disease.
“Polyamines, a group of small-molecule compounds, regulate critical biological processes, including cell proliferation, differentiation, and apoptosis, and show potential bone-protective effects.”
Review
The functional roles and mechanisms of polyamines in age-related bone diseases
Cellular and molecular life sciences : CMLS23 Dec 2025

More on Bone disease

Epithelial regeneration

upin mice1

1 study

Polyamines improve epithelial regeneration in mice.
“activation by dietary intervention or supplementation of polyamines is sufficient to enhance the regenerative capacity of aged intestines”
Animalsfollowing 5-fluorouracil-induced injuryintestine
Polyamines sustain epithelial regeneration in aged intestines by modulating protein homeostasis
Nature cell biology24 Nov 2025

Tumorigenesis

downin reviews1

1 study

Polyamines decrease tumorigenesis.
“Increased intake of polyamine seems to suppress tumorigenesis”
Review
Spermidine as a target for cancer therapy
Pharmacological research24 May 2020

Funding

2 grants since 2023

National Institute of Diabetes and Digestive and Kidney DiseasesUS$1.9m

Latest

4 in 12 months

Research9 Mar

Polyamines as a Universal Language of Host-Microbiota Symbiosis

ReviewMicrobiome composition

Nutrients27 Feb

The Diet-Microbiota-Polyamine Axis in Intestinal Aging: Microbial Pathways, Functional Foods, and Physiological Implications

ReviewMicrobiome composition

Cellular and Molecular Life Sciences23 Dec

The functional roles and mechanisms of polyamines in age-related bone diseases

ReviewBones and joints

Nature Cell Biology25 Nov

Polyamines sustain epithelial regeneration in aged intestines by modulating protein homeostasis

Experiments in miceGut and microbiome

Pharmacological Research24 May

Spermidine as a target for cancer therapy

ReviewSpermidine