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Orientin

Intervention

2 papers6 findings

PubChemChEBIMeSH

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

  • 2 independent labs in 2 countries
  • Funders: Uniwersytet Przyrodniczy we Wrocławiu and 2 more
  • Animals1
  • Cells1

Outcomes

6

Apoptosis

downin E. caballus cells1

1 study

  1. Orientin decreases apoptosis in E. caballus cells.

    “the treatment improved overall cell viability, reduced apoptotic activity, and restored both the clonogenic potential and migratory capacity of the cells”

    Cellsin EqASCs isolated from EMS-affected horsesadipose-derived stem cells

    Orientin Reverses Premature Senescence in Equine Adipose Stromal Cells Affected by Equine Metabolic Syndrome Through Oxidative Stress Modulation

    International journal of molecular sciences17 Jul 2025

More on Apoptosis

Cell proliferation

upin E. caballus cells1

1 study

  1. Orientin increases cell proliferation in E. caballus cells.

    “Orientin significantly enhanced the proliferative activity of EqASCs, as evidenced by increased Ki67 expression”

    Cellsadipose-derived stem cells

    Orientin Reverses Premature Senescence in Equine Adipose Stromal Cells Affected by Equine Metabolic Syndrome Through Oxidative Stress Modulation

    International journal of molecular sciences17 Jul 2025

Oxidative stress and ROS signalling

downin E. caballus cells1

1 study

  1. Orientin decreases oxidative stress and ROS signalling in E. caballus cells.

    “Importantly, orientin also led to a marked reduction in cellular senescence and oxidative stress”

    Cellsin EqASCs from EMS-affected horsesadipose-derived stem cells

    Orientin Reverses Premature Senescence in Equine Adipose Stromal Cells Affected by Equine Metabolic Syndrome Through Oxidative Stress Modulation

    International journal of molecular sciences17 Jul 2025

More on Oxidative stress and ROS signalling

Cellular senescence

downin E. caballus cells1

1 study

  1. Orientin decreases cellular senescence in E. caballus cells.

    “Importantly, orientin also led to a marked reduction in cellular senescence and oxidative stress”

    Cellsin EqASCs from EMS-affected horsesadipose-derived stem cells

    Orientin Reverses Premature Senescence in Equine Adipose Stromal Cells Affected by Equine Metabolic Syndrome Through Oxidative Stress Modulation

    International journal of molecular sciences17 Jul 2025

More on Cellular senescence

Inflammation

downin rats1

1 study

  1. Orientin decreases inflammation in rats.

    “reduced synovial inflammation and osteophyte in an ACLT rat model.”

    Animalsin an ACLT rat model

    Orientin alleviates chondrocyte senescence and osteoarthritis by inhibiting PI3K/AKT pathway

    Bone & joint research14 Mar 2025

More on Inflammation

Cartilage wear

downin rats1

1 study

  1. Orientin decreases cartilage wear in rats.

    “orientin improved cartilage wear and reduced synovial inflammation and osteophyte in an ACLT rat model.”

    Animalsin an ACLT rat model

    Orientin alleviates chondrocyte senescence and osteoarthritis by inhibiting PI3K/AKT pathway

    Bone & joint research14 Mar 2025

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