protein synthesis
is required forin mice1
Nitric oxide is required for protein synthesis in mice.
“Nitric oxide required for transition to slower hepatic protein synthesis rates during long-term caloric restriction”
Animalsduring caloric restrictionliver
The Journal of clinical investigation2 Jan 2026
Flow-mediated dilation
downin humans1
Nitric oxide inhibits flow-mediated dilation in humans.
“Exogenous treatment with a sub-dilator dose of NO blocked FMD in vessels from subjects with CAD”
Human trialin microvessels from subjects with CADcoronary or adipose arterioles
Basic research in cardiology19 Dec 2016
National Institute on AgingUS$2.1m
Across 60 healthy younger and older adults in the UK and Belgium, researchers found shared bacterial associations with cognitive performance despite geographic microbiome…Across 60 healthy younger and older adults in the UK and Belgium, researchers found shared bacterial associations with cognitive performance despite geographic microbiome differences.
In mouse models, alternate-day fasting stimulated hepatocyte nitric oxide production to suppress stellate cell activation, an effect abolished by hepatocyte eNOS…In mouse models, alternate-day fasting stimulated hepatocyte nitric oxide production to suppress stellate cell activation, an effect abolished by hepatocyte eNOS deletion.
Aged mice on a high-fat diet and L-NAME showed impaired mitochondrial proteostasis rather than defective biogenesis, suggesting quality control may contribute to reduced…Aged mice on a high-fat diet and L-NAME showed impaired mitochondrial proteostasis rather than defective biogenesis, suggesting quality control may contribute to reduced cardiac reserve.