Ginsenoside RB1

1. Ginsenoside RB1 decreases cellular senescence in mice.

   “Rb1 treatment significantly downregulated p21Cip1, p16INK4a, IL-6, and TNF-α expression levels, indicating that Rb1 alleviated cellular senescence and neuroinflammation in the hippocampus.”

   Animalsdaily intraperitoneal injectionhippocampus3 monthsfemales

   Ginsenoside Rb1 Ameliorates Age-Related Cognitive Impairment Potentially by Modulating the NF-κB Signaling Pathway

   Brain and behavior·31 Mar 2026

2. Ginsenoside RB1 decreases cellular senescence in mice.

   “Furthermore, Rb1 treatment downregulated the expression of p21 in the aorta, reduced the positive area percentage of SA-β-gal positivity”

   Animalsintraperitoneal injectionaorta20 mg/kg6 weeksmalesn = 5

   Ginsenoside Rb1 attenuates arterial aging by reducing DNA damage in aged mice

   Experimental gerontology·22 Dec 2025

3. Ginsenoside RB1 decreases cellular senescence in mice.

   “Treatment with Rb1 greatly reduced the physiological changes associated with aging, such as the weight loss slowing, the inhibition of the loss of visuospatial learning and memory ability, and the senescence of brain tissues.”

   Animalsbraineight weeks

   Ginsenoside Rb1 attenuates age-associated cognitive impairment by modulating oxidative stress and the SIRT1/eNOS/NO axis

   Journal of ginseng research·26 Jun 2025

More on Cellular senescence

1. Ginsenoside RB1 inhibits NF-κB signalling in mice.

   “Rb1 administration evidently repressed the phosphorylation of NF-κB, IKKβ, and IκBα in the aging mice.”

   Animalsdaily intraperitoneal injectionhippocampus3 monthsfemales

   Ginsenoside Rb1 Ameliorates Age-Related Cognitive Impairment Potentially by Modulating the NF-κB Signaling Pathway

   Brain and behavior·31 Mar 2026

More on NF-κB signalling

1. Ginsenoside RB1 decreases neurodegeneration in mice.

   “marked neuronal loss, neurodegeneration, and uneven cytoplasm distribution of Nissl bodies in the hippocampus of aging mice, all of which were alleviated by Rb1 treatment.”

   Animalsdaily intraperitoneal injectionhippocampus3 monthsfemales

   Ginsenoside Rb1 Ameliorates Age-Related Cognitive Impairment Potentially by Modulating the NF-κB Signaling Pathway

   Brain and behavior·31 Mar 2026

1. Ginsenoside RB1 improves cognitive function in mice.

   “In the MWM test, Rb1 treatment significantly ameliorated cognitive dysfunction in aging mice compared to controls.”

   Animalsdaily intraperitoneal injectionhippocampus3 monthsfemales

   Ginsenoside Rb1 Ameliorates Age-Related Cognitive Impairment Potentially by Modulating the NF-κB Signaling Pathway

   Brain and behavior·31 Mar 2026

1. Ginsenoside RB1 decreases DNA damage response in mice.

   “Notably, Rb1 significantly alleviates the elevation of γ-H2AX (a marker of DNA double-strand breaks) in the aging aorta.”

   Animalsintraperitoneal injectionaorta20 mg/kg6 weeksmalesn = 5

   Ginsenoside Rb1 attenuates arterial aging by reducing DNA damage in aged mice

   Experimental gerontology·22 Dec 2025

More on DNA damage response

1. Ginsenoside RB1 decreases apoptosis in mice.

   “decreased the proportion of TUNEL-positive apoptotic cells”

   Animalsintraperitoneal injectionaorta20 mg/kg6 weeksmalesn = 5

   Ginsenoside Rb1 attenuates arterial aging by reducing DNA damage in aged mice

   Experimental gerontology·22 Dec 2025

More on Apoptosis

1. Ginsenoside RB1 improves aortic nanobiomechanical properties in mice.

   “AFM analysis showed that Rb1 ameliorated the aging-induced impairments in nanobiomechanical properties (including elasticity, viscosity, and surface topography) induced by aging.”

   Animalsintraperitoneal injectionaorta20 mg/kg6 weeksmalesn = 5

   Ginsenoside Rb1 attenuates arterial aging by reducing DNA damage in aged mice

   Experimental gerontology·22 Dec 2025

1. Ginsenoside RB1 decreases aortic structural remodeling in mice.

   “Compared to the Old group, Rb1 significantly alleviated structural remodeling of the aging aorta, restoring smooth muscle cell alignment and extracellular matrix.”

   Animalsintraperitoneal injectionaorta20 mg/kg6 weeksmalesn = 5

   Ginsenoside Rb1 attenuates arterial aging by reducing DNA damage in aged mice

   Experimental gerontology·22 Dec 2025

1. Ginsenoside RB1 increases SIRT1 in mice.

   “Rb1 therapy raised serum NO levels and improved Sirtuin 1 (SIRT1) protein expression”

   Animalseight weeks

   Ginsenoside Rb1 attenuates age-associated cognitive impairment by modulating oxidative stress and the SIRT1/eNOS/NO axis

   Journal of ginseng research·26 Jun 2025

More on SIRT1

1. Ginsenoside RB1 decreases malondialdehyde in mice.

   “Mice treated with Rb1 had lower serum levels of malondialdehyde (MDA) and higher superoxide dismutase (SOD) activity”

   Animalseight weeks

   Ginsenoside Rb1 attenuates age-associated cognitive impairment by modulating oxidative stress and the SIRT1/eNOS/NO axis

   Journal of ginseng research·26 Jun 2025

More on Malondialdehyde