Fingolimod
- 2 independent labs in 2 countries
- Funders: Kaohsiung Veterans General Hospital and 1 more
- Animals3
Outcomes
7Healthspan
upin worms1
1 study
Healthspan
upin worms1
Fingolimod improves healthspan in worms.
“Fingolimod improved age-associated phenotypes in C. elegans”
Model organisms
bioRxiv : the preprint server for biology13 Jul 2026Preprint
Lifespan
upin mice1
1 study
Lifespan
upin mice1
Fingolimod extends lifespan in mice.
“Fingolimod improved age-associated phenotypes in C. elegans and prolonged lifespan in aged male mice”
Animalsmales
bioRxiv : the preprint server for biology13 Jul 2026Preprint
Neurodegenerative disease
downin mice1
1 study
Neurodegenerative disease
downin mice1
Fingolimod decreases neurodegenerative disease in mice.
“reduced neuroinflammatory and neurodegenerative phenotypes in Npc1 mutant mice”
Animalsin Npc1 mutant mice
bioRxiv : the preprint server for biology13 Jul 2026Preprint
anti-Müllerian hormone
upin mice1
1 study
anti-Müllerian hormone
upin mice1
Fingolimod increases anti-Müllerian hormone in mice.
“In aged mice, FTY720 treatment increased follicle numbers, improved oocyte mitochondrial quality, and elevated serum AMH levels.”
Animals
Reprogramming the aging ovarian microenvironment via mitochondrial sharing and structural remodeling
Theranostics16 Aug 2025
Oxidative phosphorylation
upin human cells1
1 study
Oxidative phosphorylation
upin human cells1
Fingolimod increases oxidative phosphorylation in human cells.
“FTY720 enhanced TNT formation and mitochondrial delivery, restoring ATP levels, membrane potential, and oxidative phosphorylation in aged cells.”
Cellsin aged cells
Reprogramming the aging ovarian microenvironment via mitochondrial sharing and structural remodeling
Theranostics16 Aug 2025
Motor neuron function
upin mice1
1 study
Motor neuron function
upin mice1
Fingolimod improves motor neuron function in mice.
“improves motor neuron function in NPC mouse models, as evidenced by performance in balance beam and vertical screen tests”
AnimalsNPC mouse models
GSA 2024 abstract31 Dec 2024
Muscle mass loss
downin mice1
1 study
Muscle mass loss
downin mice1
Fingolimod decreases muscle mass loss in mice.
“delays muscle mass decline”
AnimalsNPC mouse models
GSA 2024 abstract31 Dec 2024