Chemotherapy

Intervention5 papers5 findings

  • Human trial1
  • Humans4

Outcomes

4

Physical function

downin humans1Low certainty

1 study

  1. Chemotherapy impairs physical function in humans (-7.1 at year 1).

    Humansyear 1females

    Lifestyle and chemotherapy shape functional aging trajectories in older breast cancer survivors and matched comparators · Journal of the National Cancer Institute · 22 Sep 2026

Hannum's clock

upin humans1Very low certainty

1 study

  1. Chemotherapy increases Hannum's clock in humans (p = 0.02).

    Human trialin women with breast cancer

    p16INK4a and DNA methylation clocks in women treated with chemotherapy for early breast cancer · GeroScience · 10 Sep 2026

Hannum's clock →

p16INK4a

upin humans1Very low certainty

1 study

  1. Chemotherapy increases p16INK4a in humans.

    Human trialin women with breast cancer3-6 months

    p16INK4a and DNA methylation clocks in women treated with chemotherapy for early breast cancer · GeroScience · 10 Sep 2026

p16INK4a →

Nonsynonymous variants

upin humans1Low certainty

1 study

  1. Chemotherapy increases nonsynonymous variants in humans.

    Humansin normal tissues of children

    Extensive and differential platinum chemotherapy mutagenesis in livers of children · Science (New York, N.Y.) · 10 Sep 2026

Nonsynonymous variants →

Associations

1

Overall survival

upin humans1Low certainty

1 study

  1. Chemotherapy is associated with overall survival in humans.

    Humanshigh-risk breast cancer identified by FINE Index

    The FINE Index: A Frailty- and Immunonutrition-Based Nomogram for Survival in Geriatric Breast Cancer: A Retrospective Study · Cancer medicine · 1 Sep 2026

Trials

150

In trials

  • Breast Neoplasms

    Phase 4 · Completed · 14 trials

  • Neoplasm

    Phase 4 · Status unknown · 5 trials

  • Esophageal Neoplasms

    Phase 4 · Completed · 4 trials

  • non-Hodgkin lymphoma

    Phase 4 · Completed · 4 trials

  • Gastrointestinal Neoplasms

    Phase 4 · Status unknown · 3 trials

  • Oropharyngeal Neoplasms

    Phase 4 · Status unknown · 2 trials

40 of 54

  • Adenocarcinoma

    Phase 4 · Status unknown · 1 trial

  • Extranodal NK/T-cell lymphoma

    Phase 4 · Status unknown · 1 trial

  • Insulin resistance

    Phase 4 · Completed · 1 trial

  • Pain

    Phase 4 · Terminated · 1 trial

  • Colorectal neoplasm

    Phase 3 · Results posted · 10 trials

  • Non-Small-Cell Lung Carcinoma

    Phase 3 · Completed · 8 trials

  • Ovarian Neoplasms

    Phase 3 · Results posted · 7 trials

  • Esophageal squamous cell carcinoma

    Phase 3 · Completed · 5 trials

  • Head and Neck Neoplasms

    Phase 3 · Completed · 5 trials

  • Leukemia, Myeloid, Acute

    Phase 3 · Completed · 5 trials

  • Nasopharyngeal carcinoma

    Phase 3 · Active, not recruiting · 5 trials

  • Neoplasm Metastasis

    Phase 3 · Completed · 5 trials

  • Squamous Cell Carcinoma of Head and Neck

    Phase 3 · Completed · 5 trials

  • Lung Neoplasms

    Phase 3 · Completed · 4 trials

  • Stomach neoplasm

    Phase 3 · Completed · 4 trials

  • Colonic Neoplasms

    Phase 3 · Recruiting · 3 trials

  • Fallopian Tube Neoplasms

    Phase 3 · Completed · 3 trials

  • Leukemia

    Phase 3 · Results posted · 3 trials

  • Lymphoma

    Phase 3 · Completed · 3 trials

  • Pancreatic Neoplasms

    Phase 3 · Completed · 3 trials

  • Precursor Cell Lymphoblastic Leukemia-Lymphoma

    Phase 3 · Results posted · 3 trials

  • Rectal Neoplasms

    Phase 3 · Status unknown · 3 trials

  • Uterine Cervical Neoplasms

    Phase 3 · Status unknown · 3 trials

  • Adenocarcinoma Of Esophagus

    Phase 3 · Completed · 2 trials

  • Chemotherapy-induced Neutropenia

    Phase 3 · Results posted · 2 trials

  • Cholangiocarcinoma

    Phase 3 · Terminated · 2 trials

  • Glioblastoma

    Phase 3 · Results posted · 2 trials

  • Kidney Neoplasms

    Phase 3 · Completed · 2 trials

  • Lymphoma, Large B-Cell, Diffuse

    Phase 3 · Completed · 2 trials

  • Lymphoma, Large-Cell, Anaplastic

    Phase 3 · Completed · 2 trials

  • Ovarian Epithelial Carcinoma

    Phase 3 · Completed · 2 trials

  • Radiotherapy

    Phase 3 · Recruiting · 2 trials

  • Sarcoma

    Phase 3 · Recruiting · 2 trials

  • Triple Negative Breast Neoplasms

    Phase 3 · Completed · 2 trials

Readouts due

Stopped

  • NCT00380874 · Terminated · Pain

    See detailed description for termination reason

  • NCT00535275 · Terminated · Non-Small-Cell Lung Carcinoma

    Final analysis done, follow-up of patients no more necessary

  • NCT03642132 · Terminated · Ovarian Neoplasms

    Phase 3 B9991010 study was stopped due to futility of efficacy at interim analysis on 21Dec2018, and approvals of PARP inhibitors in front-line maintenance setting, Pfizer decided stopping enrollment in the B9991030 study on 19Mar2019.

  • NCT02298166 · Terminated · Leukemia, Myeloid, Acute

    The manufacturer Arog Pharmaceuticals Inc has terminated the Agreement Concerning the Support of an Investigator Initiated Trial this became valid on 2020/03/09

  • NCT00133224 · Terminated · Neoplasm Metastasis

    Accrual and treatment with CG1940/CG8711 stopped due to IDMC recommendation.

  • NCT02178397 · Terminated · Lung Neoplasms

    lack of recruitment

All 8

  • NCT04592861 · Terminated · Pancreatic Neoplasms

    Study administratively closed out by the Einstein IRB. NO US enrolling sites.

  • NCT02082522 · Terminated · Cholangiocarcinoma

    Accrual rate remaining too low

Trial sponsors

Latest

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