Chemical chaperones
2 papers3 findings
- 1 lab in 1 country
- Funders: Austrian Science Fund and others
- Animals1
Outcomes
2Vascular smooth muscle cell death
downin mice1
1 study
Vascular smooth muscle cell death
downin mice1
Chemical chaperones decrease vascular smooth muscle cell death in mice.
“Targeting ER stress response with a chemical chaperone delayed medial VSMC loss”
Animalsin two mouse models of HGPS exhibiting ubiquitous and VSMC-specific progerin expression
EMBO molecular medicine1 Apr 2019
Lifespan
upin mice1
1 study
Lifespan
upin mice1
Chemical chaperones extend lifespan in mice.
“and extended lifespan in the VSMC-specific model.”
Animalsin the VSMC-specific model
EMBO molecular medicine1 Apr 2019
Associations
1Atherosclerosis
downin mice1
1 study
Atherosclerosis
downin mice1
Chemical chaperones lower the risk of atherosclerosis in mice.
“Targeting ER stress response with a chemical chaperone delayed medial VSMC loss and inhibited atherosclerosis in both progeria models”
Animalsin two mouse models of HGPS exhibiting ubiquitous and VSMC-specific progerin expression
EMBO molecular medicine1 Apr 2019
Latest
1 in 12 monthsEMBO Molecular Medicine
Progerin accelerates atherosclerosis by inducing endoplasmic reticulum stress in vascular smooth muscle cells
Experiments in miceER unfolded protein response