PRKN
GeneHomo sapiens6 papersHGNC 8607NCBI Gene 5071Taxon 9606
- Humans1
- Cells2
Latest
9The Role of Natural Products in Ameliorating Mitochondrial Dysfunction in Diabetic Kidney Disease and the Underlying Mechanisms
ReviewMini reviews in medicinal chemistry
Therapeutic Timing at Mitochondrial Redox-Autophagy-Mitophagy Checkpoints in Age-Related Hearing Loss
ReviewMolecular neurobiology
Disrupted sphingolipid metabolism drives lysosomal and mitochondrial failure in Parkinson's disease
A preprint shows SMPD1 upregulation collapses a sphingolipid salvage pathway, causing mitophagy defects and marking aggressive motor phenotypes.
bioRxiv · Rai S et al.
Genetic architecture and molecular pathogenesis of Parkinson's disease: emerging mechanisms and therapeutic targets
ReviewMetabolic brain disease
Mitochondrial-Targeted Phytochemicals in Reproductive Aging: Mechanisms and Translational Potential
ReviewReproductive medicine and biology
Oxidative Stress and Mitochondrial Dysfunction in Chronic Kidney Disease: From Molecular Mechanisms to Biomarkers and Targeted Therapies
ReviewAntioxidants (Basel, Switzerland)
Sephin1 promotes mitophagy and reduces alpha-synuclein toxicity in Parkinson models
The compound directly binds Prohibitin-2 to activate PINK1-PRKN-dependent clearance of damaged mitochondria, easing motor deficits in transgenic mice.
Biochemical pharmacology · Ding XS et al.