An observational study compared genomes from 698 people aged 18–39 and 5,220 older adults; their tumours largely shared the same cancer-driving genetic changes.An observational study compared genomes from 698 people aged 18–39 and 5,220 older adults; their tumours largely shared the same cancer-driving genetic changes.
Preprint: cross-sectional study of 698 adolescents and young adults with cancer, against older adultsMechanisms
Limit: Age-dependent cancer subtypes could explain some apparent age differences in tumour genomes
An analysis of 69,871 melanoma cases and 1,616,233 comparison participants identified 156 independent genetic signals in 116 regions linked to risk.An analysis of 69,871 melanoma cases and 1,616,233 comparison participants identified 156 independent genetic signals in 116 regions linked to risk.
Preprint: meta-analysis of melanoma cases and comparison participants, against comparison participantsCutaneous melanoma
Limit: Gene mapping did not establish that the implicated genes cause melanoma
For one gene involved in DNA modification, 52.8% of patients flagged as carrying a mutation had no tumour-derived mutation in that gene.For one gene involved in DNA modification, 52.8% of patients flagged as carrying a mutation had no tumour-derived mutation in that gene.
Analyses of human kidney tumours, mice and cell lines showed that losing the Y chromosome produces few broad changes in gene activity across cancers.Analyses of human kidney tumours, mice and cell lines showed that losing the Y chromosome produces few broad changes in gene activity across cancers.
Applied to over 5.8 million spatially profiled cells, the framework identified a T-cell-associated brain-aging program and signals that predicted age across regions.Applied to over 5.8 million spatially profiled cells, the framework identified a T-cell-associated brain-aging program and signals that predicted age across regions.