Metastasis: aging research evidence

Interventions

1

Senolytics

downin mice1Very low certainty

1 study

Senolytics decrease metastasis in mice.
Animalsfollowing docetaxel treatment
Senolytic Interventions Enhance the Anti-metastatic Activity of Chemotherapy in Prostate Cancer · Cancer research · 21 Sep 2026

Senolytics →

Trial sponsors

AstraZeneca
Company1 trialPhase 351 people
Bayer
Company1 trialPhase 29 people
Ottawa Hospital Research Institute
1 trialPhase 4263 people
Sun Yat-sen University
1 trialPhase 2/3622 people
Asan Medical Center
1 trialPhase 255 people
Samsung Medical Center
1 trialPhase 250 people
Memorial Sloan Kettering Cancer Center
1 trialPhase 245 people
Kaohsiung Medical University Chung-Ho Memorial Hospital
1 trialPhase 215 people

Funding

National Cancer InstituteUS$1.3m2 grants since 2017

Latest

17

FoodsReview28 Sep

Exploring the Physiological Effects and Mechanisms of Gamma-Aminobutyric Acid in Food Systems

Interventions

GenesReview26 Sep

The Epigenetic Aging-Cancer Continuum: Biomarkers, Metabolism, and Therapy

NAD+ metabolism

The Journal of Investigative DermatologyHumans22 Sep

Skin Cancer Risk Stratification and Outcomes in Swedish Solid Organ Transplant Recipients

Biomarkers

Cancer ResearchAnimals21 Sep

Senolytic Interventions Enhance the Anti-metastatic Activity of Chemotherapy in Prostate Cancer

Senolytics

Clinical & Translational OncologyReview16 Sep

Prophylactic and therapeutic effects of aspirin in cancer

Cancer

CancersHumans15 Sep

The Association of FIT-Based Colorectal Cancer Screening with Earlier Disease Detection: The Romanian Experience

Colorectal cancer

HealthcareHumans15 Sep

Turkish Cross-Cultural Adaptation of the BRIEF-MPI in Older Adults with Cancer: Convergent and Discriminative Validity Compared with the G8 and Clinical Frailty Scale

Clinical Frailty Scale

Cancer ReportsReview13 Sep

A Review of Senescence-Associated Secretory Phenotype-Mediated Remodeling of the Tumor Microenvironment: Implications for Cancer Progression and Therapy

Senescence-associated secretory phenotype (SASP)

Cancer ControlAnimals4 Sep

Voluntary Wheel Running Modulates Tumour-Associated Macrophage Polarization in Breast Cancer Lung Metastases of Old BALB/C Mice, in a Dose-dependent Manner

Lung

BiogerontologyReview2 Sep

Closing the gap in aging science: unlocking the potential of nanoparticles in senescence therapy

Interventions

Metastasis

Interventions

Trial sponsors

Funding

Latest

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