3 papers3 findings
MNA/NAM ratio
upin humans1
Ovarian ageing increases MNA/NAM ratio in humans (p < 0.001).
“leading to a sharp increase of the MNA/NAM ratio (p < 0.001)”
Humansin follicular fluidfollicular fluidfemales
Nicotinamide (Vitamin B3) Deficiency in Follicular Fluid of Patients With Ovarian Ageing
Journal of cellular and molecular medicine1 Mar 2026
1-methylnicotinamide
upin humans1
Ovarian ageing increases 1-methylnicotinamide in humans (p = 0.01).
“associated by an increase in 1-methylnicotinamide concentration (p = 0.01), leading to a sharp increase of the MNA/NAM ratio (p < 0.001)”
Humansin follicular fluidfollicular fluidfemales
Nicotinamide (Vitamin B3) Deficiency in Follicular Fluid of Patients With Ovarian Ageing
Journal of cellular and molecular medicine1 Mar 2026
Nicotinamide
downin humans1
Ovarian ageing decreases nicotinamide in humans (p < 0.01).
“Nicotinamide concentration was significantly decrease in the FF of patients with ovarian ageing (p < 0.01)”
Humansin follicular fluidfollicular fluidfemales
Nicotinamide (Vitamin B3) Deficiency in Follicular Fluid of Patients With Ovarian Ageing
Journal of cellular and molecular medicine1 Mar 2026
Transplanting ovaries between younger and older mice shifted molecular age estimates in both directions, but the changes remained partial.Transplanting ovaries between younger and older mice shifted molecular age estimates in both directions, but the changes remained partial.
The peptide also boosted maturation and fertilization in aged human oocytes by activating the vitamin B6 and VEGF pathway.The peptide also boosted maturation and fertilization in aged human oocytes by activating the vitamin B6 and VEGF pathway.
A new preprint shows tamoxifen-inducible mouse models remain valid for ovarian aging research despite transient disruptions to estrous cycling.A new preprint shows tamoxifen-inducible mouse models remain valid for ovarian aging research despite transient disruptions to estrous cycling.
Researchers combined imaging, matrix profiling, and single-cell sequencing to show how ovarian fibrosis develops in women over time.Researchers combined imaging, matrix profiling, and single-cell sequencing to show how ovarian fibrosis develops in women over time.
A multi-omic analysis shows that defective luteal resolution and CHK2-driven inflammation drive ovarian aging, but drug inhibition restores oocyte maturation.A multi-omic analysis shows that defective luteal resolution and CHK2-driven inflammation drive ovarian aging, but drug inhibition restores oocyte maturation.
Using a corpus luteum tracking system in older mice, researchers linked stalled regression to persistent tissue debris, multinucleated giant cells, and localized…Using a corpus luteum tracking system in older mice, researchers linked stalled regression to persistent tissue debris, multinucleated giant cells, and localized fibroinflammation.