1-methylnicotinamide

1. Nicotinamide adenine dinucleotide increases 1-methylnicotinamide in humans (p=5.39e-13).

   “Plasma NAD catabolites increased substantially (1-methyl-nicotinamide, MeNAM p=5.39e −13 ; N1-methyl-2-pyridone-5-carboxamide, 2PY p=2.95e −16 )”

   Human trialhealthy adultsplasma5 daysn = 50

   Oral LNAD+ Rapidly Elevates Intracellular NAD and Metabolic Flux Without Elevating Circulating NAD: Evidence from a Randomized Controlled Trial

   bioRxiv (Cold Spring Harbor Laboratory)·27 Mar 2026Preprint

More on Nicotinamide adenine dinucleotide

1. Ovarian ageing increases 1-methylnicotinamide in humans (p = 0.01).

   “associated by an increase in 1-methylnicotinamide concentration (p = 0.01), leading to a sharp increase of the MNA/NAM ratio (p < 0.001)”

   Humansin follicular fluidfollicular fluidfemales

   Nicotinamide (Vitamin B3) Deficiency in Follicular Fluid of Patients With Ovarian Ageing

   Journal of cellular and molecular medicine·1 Mar 2026

More on Ovarian ageing

1. 1-methylnicotinamide is associated with processing speed in humans (attenuated the association by ≥10-14%).

   “lower levels of maslinic acid, 1-methylnicotinamide (myokine derived from vitamin B3), and C20:5 lysophosphatidylcholine (lysophospholipid containing omega-3 fatty acid) were associated with higher IMF and worse DSST.”

   Humansmediates IMF-DSST association by ≥10-14%n = 2,388

   INTER-RELATIONSHIPS OF CIRCULATING PLASMA METABOLITES, INTERMUSCULAR FAT, AND PROCESSING SPEED: HEALTH ABC STUDY

   GSA 2024 abstract·31 Dec 2024