Early-onset Alzheimer's disease
Disease1 paper1 finding
- Humans1
Associations
1Posterior parietal and lateral temporal cortical thickness
downin humans1
1 study
Posterior parietal and lateral temporal cortical thickness
downin humans1
Early-onset Alzheimer's disease is associated with posterior parietal and lateral temporal cortical thickness in humans.
Humansbiomarker-confirmed early-onset Alzheimer's dementiacerebral cortex
Brain thinning detected before dementia in people under 65 · Journal of neurology · 7 Oct 2026
Posterior parietal and lateral temporal cortical thickness →
Trial sponsors
Company1 trialPhase 1/215 people
Company1 trialPhase 1144 people
Assistance Publique - Hôpitaux de Paris
1 trialPhase 3240 people
1 trialPhase 2/3240 people
Washington University School of Medicine
1 trialPhase 248 people
Funding
National Institute on AgingUS$1.4m3 grants since 2019
National Institute on AgingWake Forest University Health SciencesUS$520k2019–2027
Behavioral Interventions for the Treatment of Early Onset Alzheimer's Disease
National Institute on AgingIndiana University IndianapolisUS$165k2023–2028
National Institute on AgingUniversity of MinnesotaUS$694.7k2023–2027
Latest
3Brain thinning detected before dementia in people under 65
An observational study of 292 people under 65 linked two positive Alzheimer’s-related spinal-fluid tests to earlier and more extensive thinning.An observational study of 292 people under 65 linked two positive Alzheimer’s-related spinal-fluid tests to earlier and more extensive thinning.