Tau accumulation rate

1. Early-onset Alzheimer's disease increases tau accumulation rate in humans.

   “EOAD participants exhibited a faster increase in 18 F‐Flortaucipir binding than LOAD, predominantly in frontal and occipital areas”

   Humansin amyloid-beta PET-positive cognitively impaired participantsfrontal and occipital cortex1.95 to 2.44 years

   Tau PET load in early‐ and late‐onset Alzheimer's disease: A cross‐sectional and longitudinal comparison of the LEADS and ADNI cohorts

   AAIC 2025 abstract·7 Jan 2026

More on Early-onset Alzheimer's disease

1. Tau accumulation rate is associated with immediate recall in humans.

   “Immediate Recall (LM) decline was significantly only associated with tau accumulation”

   Humansnon-demented individuals

   Implementation of NIA‐AA Multilevel Tau Staging for Predicting Tau Accumulation and Cognitive Decline in Non‐Demented Individuals

   AAIC 2025 abstract·8 Jan 2026