Mutational burden

Biomarker

1 paper1 finding

Cells1

Interventions

Radiation

no changein human cells1

1 study

Radiation has no effect on mutational burden in human cells.
Cellsskeletal muscle stem cells10 and 100 mGy
Effects of low-dose γ-radiation on skeletal muscle stem cells
International journal of radiation biology19 Aug 2026

Latest

21 in 12 months

bioRxiv2 Oct

Single-neuron sequencing reveals widespread low-frequency somatic mutations in dementia brains

Human neurons from frontotemporal lobar degeneration patients showed ultra-low-frequency TARDBP variants that were less abundant in individuals who died at older ages.Human neurons from frontotemporal lobar degeneration patients showed ultra-low-frequency TARDBP variants that were less abundant in individuals who died at older ages.

Preprint: case-control study in peopleMechanisms

Paper

bioRxiv2 Oct

Human neurons accumulate far more mutations over lifespan than shorter-lived mammals

Cortical neurons gain mutations at similar yearly rates across six species, leaving aged humans with uniquely high mutational burdens and transcriptomic dysregulation.Cortical neurons gain mutations at similar yearly rates across six species, leaving aged humans with uniquely high mutational burdens and transcriptomic dysregulation.

Preprint: study in peopleMechanisms

Paper

Haematologica1 Oct