Tau load

1. Early-onset Alzheimer's disease increases tau load in humans.

   “EOAD participants had higher 18 F‐Flortaucipir levels in widespread neocortical regions compared to LOAD, after adjusting for covariates.”

   Humansin amyloid-beta PET-positive cognitively impaired participants, adjusted for covariatesneocortex

   Tau PET load in early‐ and late‐onset Alzheimer's disease: A cross‐sectional and longitudinal comparison of the LEADS and ADNI cohorts

   AAIC 2025 abstract·7 Jan 2026

More on Early-onset Alzheimer's disease

1. Age is associated with tau load in humans.

   “In both groups, tau load was negatively associated with age.”

   Humansin both EOAD and LOAD participants

   Tau PET load in early‐ and late‐onset Alzheimer's disease: A cross‐sectional and longitudinal comparison of the LEADS and ADNI cohorts

   AAIC 2025 abstract·7 Jan 2026