In male mice fed a high-fat diet from 6 to 12 months of age, oral bacterial supplementation reduced weight gain and memory impairments.In male mice fed a high-fat diet from 6 to 12 months of age, oral bacterial supplementation reduced weight gain and memory impairments.
Experiments in male wild-type C57BL/6J mice, 6 consecutive months, against the HFD groupGut and microbiome
Limit: Serum metabolomics was not measured in the high-fat diet or Akk supplementation groups
In six-month-old mice with accelerated aging, ER272 was linked to better cognition and preserved markers of new brain cells in males, but showed limited effects in…In six-month-old mice with accelerated aging, ER272 was linked to better cognition and preserved markers of new brain cells in males, but showed limited effects in females.
In people with osteoporosis, higher undercarboxylated osteocalcin correlated with greater medial prefrontal cortex volume, which predicted one-year cognitive decline with…In people with osteoporosis, higher undercarboxylated osteocalcin correlated with greater medial prefrontal cortex volume, which predicted one-year cognitive decline with an AUC of 0.84.
Clearing these peripheral myeloid cells remodeled brain macrophages and improved cognitive performance without requiring the engineered immune cells to enter the brain.Clearing these peripheral myeloid cells remodeled brain macrophages and improved cognitive performance without requiring the engineered immune cells to enter the brain.