Spermine

Biomarker

11 papers2 findings

MeSH

  • Human trial1
  • Animals8

Interventions

2

Polyamines

upin humans1

1 study
  1. Polyamines increase spermine in humans.

    “increased polyamine intake (spermidine much more so than spermine) over a long period increased blood spermine levels”

    Reviewlong period

    Overview of Polyamines as Nutrients for Human Healthy Long Life and Effect of Increased Polyamine Intake on DNA Methylation

    CellsJan 4, 2022

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Polyamine-rich diet

upin humans1

1 study
  1. Polyamine-rich diet increases spermine in humans (1.12 ± 0.29 times, p = 0.019).

    “The mean blood spermine level in the intervention group gradually rose to 1.12 ± 0.29 times the pre-intervention level after 12 months, and were significantly higher (p = 0.019) than those in the control group.”

    Human trialnattowhole blood12 monthsmalesn = 30

    Polyamine-Rich Diet Elevates Blood Spermine Levels and Inhibits Pro-Inflammatory Status: An Interventional Study

    Medical sciences (Basel, Switzerland)Mar 29, 2021

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Funding

1 grant since 2022

Japan Society for the Promotion of ScienceJP¥4.2m

Latest

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European Heart Journal Open

Spermidine is linked to higher fitness in coronary artery disease

Each doubling of spermidine intake was associated with 2.6 millilitres per kilogram per minute higher peak oxygen uptake in older people with coronary artery disease.Each doubling of spermidine intake was associated with 2.6 millilitres per kilogram per minute higher peak oxygen uptake in older people with coronary artery disease.

Cohort study of 187 peopleCoronary artery disease