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HGNC 15862 NCBI Gene 54498 Taxon 9606

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Neuropharmacology and Therapy·22 Aug

Polyamine Metabolism in Brain Health and Disease

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ATP13A21
Alzheimer's disease1
Autophagy1
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Lysosome1
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ODC11
Oxidative stress and ROS signalling1
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Proteostasis1
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Hypotonia1
Intellectual disability1
Movement disorders1

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ER-100 glaucoma trial findings support testing higher dosesTrialsLongevity.Technology and 3 more

New immune cell map reveals how individual immune aging trajectories divergeResearchMedical Xpress and 2 more

Newer cohorts of older Europeans show slower intrinsic capacity lossResearchThe Lancet Healthy Longevity

Trials

AKG and Brain Health in AgingPhase 2Registered 6 Oct 2026, University of Oklahoma Safety and Preliminary Efficacy of Adipose-Derived Stem Cell Secretome in Frailty (VinVital)Phase 1Registered 2 Oct 2026, Vinmec Research Institute of Stem Cell and Gene Technology AI-Based Conversational Social Support for Older Adults With Heart FailureRegistered 7 Oct 2026, Chang Gung University of Science and Technology

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Vitamin D deficiencyDiseaseSevere vitamin D deficiency is linked to higher death rates, and 1 more story this week Ketogenic dietInterventionKetogenic diet improved heart function in aged mice Nicotinamide ribosideInterventionNicotinamide riboside did not improve early Parkinson disease TERTGeneBlood-cell telomerase delays premature aging in zebrafish PregnancyInterventionEstimated brain-age gap rises by three years in pregnancy Childhood lonelinessInterventionChildhood loneliness linked to faster frailty progression

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