Smooth muscle cells

1. Navitoclax decreases smooth muscle cells in mice (-90%).

   “However, ABT-263 treatment reduced SMC by 90% and increased EC contributions to lesions via EC-to-mesenchymal transition (EndoMT) by 60%.”

   Animalsin western diet-fed Apoe-/- mice with advanced atherosclerosisbrachiocephalic artery100 mg/kg/bw or 50 mg/kg/bw6 weeks or 9 weeks

   Treatment of advanced atherosclerotic mice with ABT-263 reduced indices of plaque stability and increased mortality

   JCI insight·23 Jan 2024

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1. FARNESYL-PRELAMINA has no effect on smooth muscle cells in mice.

   “In contrast, farnesyl-prelamin A in Zmpste24 -/- mice does not cause SMC loss-even at 21 weeks of age.”

   AnimalsZmpste24 -/- miceaorta

   The Accumulation of Progerin Underlies the Loss of Aortic Smooth Muscle Cells in Hutchinson-Gilford Progeria Syndrome

   bioRxiv : the preprint server for biology·3 Nov 2024Preprint

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1. LMNA decreases smooth muscle cells in mice.

   “In a mouse model of HGPS (Lmna G609G), progerin causes loss of aortic smooth muscle cells (SMCs) by ~12 weeks of age.”

   AnimalsLmna G609G miceaorta

   The Accumulation of Progerin Underlies the Loss of Aortic Smooth Muscle Cells in Hutchinson-Gilford Progeria Syndrome

   bioRxiv : the preprint server for biology·3 Nov 2024Preprint

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