1 paper
Mice with one working copy of the protein’s gene had enlarged, scarred hearts and poorer pumping, resembling changes in aged mice.Mice with one working copy of the protein’s gene had enlarged, scarred hearts and poorer pumping, resembling changes in aged mice.
Increasing the protein’s production in rat cells grown in the lab restored testosterone output and reversed signs of senescence, a state in which cells stop dividing.Increasing the protein’s production in rat cells grown in the lab restored testosterone output and reversed signs of senescence, a state in which cells stop dividing.
High UHRF1 expression causes stable senescence sensitive to Navitoclax, while cells with lower expression proliferate if tp53 is mutated.High UHRF1 expression causes stable senescence sensitive to Navitoclax, while cells with lower expression proliferate if tp53 is mutated.