Senescence
Biomarker4 papers
- Animals3
- Cells1
Funding
National Institute on AgingUS$22.6mNational Heart, Lung, and Blood InstituteUS$6.6mNational Institute of Diabetes and Digestive and Kidney DiseasesUS$5.6m94 grants since 2001
Crosstalk of senescence and DNA methylation promotes cyst growth in ADPKD
National Institute of Diabetes and Digestive and Kidney DiseasesMayo Clinic RochesterUS$607.5k2020–2030
Single-cell label-free identification of senescence by Raman microscopy and spatial genomics
National Cancer InstituteMassachusetts Institute of TechnologyUS$500k2022–2027
National Institute of Child Health and Human DevelopmentVirginia Commonwealth UniversityUS$749.1k2023–2028
A novel AI platform to detect cellular senescence and measure biological age using biofluids
National Institute on AgingSenescope, Inc.US$396.6k2026–2027
Cellular Senescence in Alzheimer's Disease: Detection and Characterization
National Institute on AgingIcahn School of Medicine at Mount SinaiUS$832.1k2026–2027
National Institute on AgingUniversity of ColoradoUS$810k2026–2031
Caloric Restriction-Regulated Non-Coding RNAs as Modulators of Adipose Tissue Aging and Senescence
National Institute on AgingBeth Israel Deaconess Medical CenterUS$106.6k2026–2031
The Post-Lung Transplant Impact of Alveolar Macrophage Senescence in Aged Donor Lungs
National Heart, Lung, and Blood InstituteDuke UniversityUS$154.4k2025–2030
National Institute of Diabetes and Digestive and Kidney DiseasesUniversity of Michigan at Ann ArborUS$779.3k2022–2031
National Institute of Diabetes and Digestive and Kidney DiseasesUniversity of Wisconsin-madisonUS$41.2k2025–2028
Latest
607Protein deficiency impaired memory in aging mice
Experiments in 15-month-old mice with reduced Nipsnap1, a protein involved in cell maintenance, found reduced gene activity linked to nerve-cell…Experiments in 15-month-old mice with reduced Nipsnap1, a protein involved in cell maintenance, found reduced gene activity linked to nerve-cell signalling and increased activity linked to inflammation.
New protein form pushed lab-grown cells to stop dividing
Cell experiments identified a previously unknown protein form that responded to DNA damage and triggered senescence, a state in which cells stop…Cell experiments identified a previously unknown protein form that responded to DNA damage and triggered senescence, a state in which cells stop dividing.
Human protein variant eased signs of progeria in mice
An animal experiment in genetically engineered mice found that the variant prevented characteristic tissue changes and modestly increased median…An animal experiment in genetically engineered mice found that the variant prevented characteristic tissue changes and modestly increased median lifespan.
Resveratrol reversed some toxin effects in lab-grown liver cells
Experiments in human and pig liver cells found that resveratrol’s ability to reverse toxin-induced changes depended on the species and liver function…Experiments in human and pig liver cells found that resveratrol’s ability to reverse toxin-induced changes depended on the species and liver function measured.
Protein loss promotes a non-dividing state in kidney cells
The study reported that loss of a protein in cells’ energy-producing structures triggered persistent, harmful stress signalling in kidney-filtering…The study reported that loss of a protein in cells’ energy-producing structures triggered persistent, harmful stress signalling in kidney-filtering cells.
Biological aging and frailty linked to thinner central retinas
Blood metabolic profiles statistically accounted for 81.14% of the link with one biological age measure, compared with 19.92% for another and 32.27%…Blood metabolic profiles statistically accounted for 81.14% of the link with one biological age measure, compared with 19.92% for another and 32.27% for frailty.
Placentas showed faster molecular aging in late-onset preeclampsia
An analysis of placental tissue linked the pregnancy complication to shorter chromosome ends, DNA damage and cells that had stopped dividing.An analysis of placental tissue linked the pregnancy complication to shorter chromosome ends, DNA damage and cells that had stopped dividing.