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Protein loss promotes age-linked brain cell activation in mice

In experiments, aged mice lacking the protein showed stronger age-linked brain cell activation, but no obvious loss of nerve insulation or faster decline in movement.In experiments, aged mice lacking the protein showed stronger age-linked brain cell activation, but no obvious loss of nerve insulation or faster decline in movement.

Limit: The experiments did not distinguish adaptive activation from early, compensated persistent activation

Herbal mixture may ease frailty in mice modelling Alzheimer's

In a 194-day experiment, Qi-Fu-Yin improved movement and strength in mice genetically modified to model Alzheimer's disease.In a 194-day experiment, Qi-Fu-Yin improved movement and strength in mice genetically modified to model Alzheimer's disease.

Extracellular cGAMP drives neuroinflammation and premature aging phenotypes in mice

Loss of the cGAMP-degrading enzyme ENPP1 allows microglia-derived signaling molecules to trigger STING-dependent inflammation across multiple brain cell types.Loss of the cGAMP-degrading enzyme ENPP1 allows microglia-derived signaling molecules to trigger STING-dependent inflammation across multiple brain cell types.