Muscle mass
Biomarker1 paper
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12Genetically predicted TNF-beta protects against sarcopenia traits in humans
A Mendelian randomization analysis of 91 circulating inflammatory markers identified tumor necrosis factor-beta as causally linked to better muscle mass, grip strength, and walking pace.
Loss of ULK1 and ULK2 drives muscle growth in mice but impairs force
While lifelong depletion reduced muscle strength, short-term deficiency in adult mice induced hypertrophy without degrading muscle quality or contractile performance.
Inhibiting miR-128-3p restores muscle mass and function in aged mice
The microRNA inhibitor also improved cardiac outcomes after infarction and reduced pathology in mouse and pig models of muscular dystrophy.
Depp1 drives muscle loss under fasting and low oxygen in mice
The study reveals that the protein localizes to mitochondria to regulate autophagy and mitochondrial degradation during nutrient and oxygen limitation.
Loss of myofibril number drives muscle fibre atrophy during aging and disuse
Structural analyses of humans and mice reveal that fibers shrink primarily by shedding myofibrils rather than reducing myofibril size.