7 papers1 finding
Cerebrovascular events
upin humans1
Proteomic signatures predict cerebrovascular events in humans.
“a subset detected in plasma predicted future cerebrovascular events in the UK Biobank better than risk scores currently used in clinical practice”
Humansplasma
Nature aging24 Feb 2026
National Institute on AgingUS$5.1mNorges ForskningsrådNOK 7mJapan Society for the Promotion of ScienceJP¥4.2m
National Institute on AgingYale UniversityUS$948.5k2023–2027
American Heart AssociationSalk Institute for Biological StudiesUS$70k2023–2025
Proteomic Signatures for Osteosarcopenia
Japan Society for the Promotion of ScienceKeio UniversityJP¥4.2m2021–2024
Proteomic signatures to identify pathways underlying the progression to heart failure
Norges ForskningsrådUniversity of OsloNOK 7m2021–2026
Higher sleep-linked protein scores were associated with a lower depression rate during follow-up (hazard ratio 0.660); the abstract did not specify the comparison group.Higher sleep-linked protein scores were associated with a lower depression rate during follow-up (hazard ratio 0.660); the abstract did not specify the comparison group.
People with poor heart and metabolic health and pre-frailty or frailty had a heart failure hazard ratio of 2.76 versus healthy, non-frail participants.People with poor heart and metabolic health and pre-frailty or frailty had a heart failure hazard ratio of 2.76 versus healthy, non-frail participants.
In a study of UK adults, the highest fitness quartile had a 24% lower depression risk and 17% lower anxiety risk than the lowest quartile.In a study of UK adults, the highest fitness quartile had a 24% lower depression risk and 17% lower anxiety risk than the lowest quartile.
Blood proteins statistically accounted for 0.5 to 50.7% of the risk associated with biological aging measures.Blood proteins statistically accounted for 0.5 to 50.7% of the risk associated with biological aging measures.
In an observational study of 4,100 people, accelerated blood protein aging tracked worsening kidney function, blood lipid imbalances, and a higher risk of death.In an observational study of 4,100 people, accelerated blood protein aging tracked worsening kidney function, blood lipid imbalances, and a higher risk of death.
Links to heart attacks were stronger at lower kidney function for 154 blood proteins and at higher function for 22.Links to heart attacks were stronger at lower kidney function for 154 blood proteins and at higher function for 22.
In over 36,000 UK Biobank participants, the signature raised Harrell's C-index from 0.798 to 0.862, carrying a hazard ratio of 2.645 per standard deviation increase.In over 36,000 UK Biobank participants, the signature raised Harrell's C-index from 0.798 to 0.862, carrying a hazard ratio of 2.645 per standard deviation increase.
In an older Scottish cohort, epigenetic age and brain volume outmatched plasma proteomic organ clocks for predicting long-term all-cause mortality.In an older Scottish cohort, epigenetic age and brain volume outmatched plasma proteomic organ clocks for predicting long-term all-cause mortality.