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Thursday, November 5

medRxiv

Waist-to-height ratio linked to risk beyond body mass index

Among adults with normal body mass index, elevated waist-to-height ratios were linked to higher diabetes rates during follow-up, with a hazard ratio of 1.74 versus lower…Among adults with normal body mass index, elevated waist-to-height ratios were linked to higher diabetes rates during follow-up, with a hazard ratio of 1.74 versus lower ratios.

Adults with broader and narrower waists surround blood samples containing cells and contrasting dense and sparse clusters of sugar shapes.
Preprint: cohort · 77,684 peopleWaist-to-height ratio
Paper
The Journal of Clinical Investigation

Patient muscles show early signs of cell senescence

An analysis of patient muscle gene activity found senescence-related patterns linked to disease severity and present even without inflammation visible on scans.An analysis of patient muscle gene activity found senescence-related patterns linked to disease severity and present even without inflammation visible on scans.

Muscle tissue with full, tightly packed fibers beside shrunken fibers tangled in scarring and clustered immune cells, with a small mouse below.
Cross-sectional studyCellular senescence
Paper
Cell Stem Cell

Gene silencing lasts and partly reverses in human blood stem cells

Silencing of a platelet-related gene remained stable four months after human stem cells were transplanted into mice.Silencing of a platelet-related gene remained stable four months after human stem cells were transplanted into mice.

Figure from Cell Stem Cell
Human cell studyInterventions
Paper
Molecular Biomedicine

Exercise-linked protein helped protect hearts in mice

Mice that exercised for 12 weeks before heart blood flow was interrupted and restored had better heart function and smaller areas of dead tissue.Mice that exercised for 12 weeks before heart blood flow was interrupted and restored had better heart function and smaller areas of dead tissue.

Long-term aerobic exercise preconditioning attenuates myocardial ischemia–reperfusion injury and GSDME-associated pyroptotic signaling.
Mouse studyAerobic exercise
Paper