Isometric handgrip exercise

2 papers6 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab
1 finding against

Human trial2

Outcomes

Blood pressure

downin humans1upin humans1

1 study

Isometric handgrip exercise decreases blood pressure in humans.
Human trialone hour post exercise30% of maximal voluntary contractionn = 87
Immediate Cardiovascular Responses to Isometric Handgrip Exercise in Young Adults in Puri, Odisha: A Cross-Sectional Study
Cureus5 Jul 2026
Isometric handgrip exercise increases blood pressure in humans.
Human trialduring exercise30% of maximal voluntary contractionn = 87
Immediate Cardiovascular Responses to Isometric Handgrip Exercise in Young Adults in Puri, Odisha: A Cross-Sectional Study
Cureus5 Jul 2026

Adverse reactions

upin humans1

1 study

Isometric handgrip exercise increases adverse reactions in humans (30% with 3-minute contractions versus 20% with 2-minute contractions).
Human trialPrehypertension and substance use disorder30% MVC, 4 × 3 min versus 4 × 2 minAcute sessionmalesn = 9
Dose–effect relationship of an acute isometric exercise session with different durations on blood pressure and arterial stiffness in prehypertensive substance use disorder individuals
Scientific reports9 Oct 2026

24-hour ambulatory systolic blood pressure

downin humans1

1 study

Isometric handgrip exercise decreases 24-hour ambulatory systolic blood pressure in humans (−5.8 mmHg mean 24-hour ambulatory SBP).
Human trialPrehypertension and substance use disorder30% MVC, 4 × 2 min, 2 min rest between sets24 hoursmalesn = 9
Dose–effect relationship of an acute isometric exercise session with different durations on blood pressure and arterial stiffness in prehypertensive substance use disorder individuals
Scientific reports9 Oct 2026

More on 24-hour ambulatory systolic blood pressure

Office systolic blood pressure

downin humans1

1 study

Isometric handgrip exercise decreases office systolic blood pressure in humans (−11.7 mmHg at 1 hour; office blood pressure-lowering effect lasted 24 hours).
Human trialPrehypertension and substance use disorder30% MVC, 4 × 2 min, 2 min rest between sets1 hour post-exercisemalesn = 9
Dose–effect relationship of an acute isometric exercise session with different durations on blood pressure and arterial stiffness in prehypertensive substance use disorder individuals
Scientific reports9 Oct 2026