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Programming

Papers on Programming

19,972 papers944 new in 30 days

Wednesday, November 4

Research Square

Mobility program linked to less functional decline in older inpatients

Functional worsening at discharge occurred in 29.7% of older patients after the program began, compared with 49.7% before it.Functional worsening at discharge occurred in 29.7% of older patients after the program began, compared with 49.7% before it.

Study flow diagram Flow diagram showing patient screening, exclusions, safety population, and discharged-alive, analytic cohort before and after implementation of the HESM pathway.
Preprint: cohort · 600 peopleInterventions
Paper

Tuesday, November 3

medRxiv

Metformin linked to lower dementia risk in US health records

Metformin’s dementia hazard ratio—a comparison of risk over time—was 0.90 versus sulfonylurea diabetes drugs; the range of likely values included no difference.Metformin’s dementia hazard ratio—a comparison of risk over time—was 0.90 versus sulfonylurea diabetes drugs; the range of likely values included no difference.

Brain cross-sections sit beside matching groups of upright people, with fuller dark blue-green folds and wider gaps in the smaller gray section.
Preprint: cohort studyDementia
Paper
NPJ Aging

Protein loss disrupts nuclear structure in primate cells

Restoring the protein’s activity restored nuclear structure and the ability to divide in cells from aged non-human primates and animals modeling a premature-aging…Restoring the protein’s activity restored nuclear structure and the ability to divide in cells from aged non-human primates and animals modeling a premature-aging disorder.

Figure from NPJ Aging
Animal cell studyMechanisms
Paper
bioRxiv

Measures of aging in cell structures linked to disease risk

Among 61,931 people, four or more prematurely aged compartments were linked to up to 22-fold higher kidney disease risk and up to 8-fold higher mortality risk.Among 61,931 people, four or more prematurely aged compartments were linked to up to 22-fold higher kidney disease risk and up to 8-fold higher mortality risk.

Kidney cross-section with intact and fragmented tissue beside mitochondria with dense or broken folds, sparse or crowded lysosomes, and curved membrane stacks.
Preprint: cohort study of 61,931 peopleBiomarkers
Paper
bioRxiv

Some blood stem cells kept immune-cell potential in aging mice

Mouse experiments identified self-renewing blood stem cells that retained a similar tendency to replenish certain immune cells during aging.Mouse experiments identified self-renewing blood stem cells that retained a similar tendency to replenish certain immune cells during aging.

A large blood stem cell sits among smaller stem cells, lymphocytes, a separate gray cell cluster, and laboratory mice of different sizes.
Preprint: mouse studyImmune response
Paper
bioRxiv

Age linked to shifts in heart immune-cell gene activity in mice

An experiment in young and aged mice found both higher and lower activity in gene programs in heart immune cells 24 hours after an inflammatory challenge.An experiment in young and aged mice found both higher and lower activity in gene programs in heart immune cells 24 hours after an inflammatory challenge.

Heart sections beside laboratory mice show immune cells and dark blue-green mitochondria on one side, larger immune cells and gray mitochondria on the other.
Preprint: mouse studyImmune response
Paper
bioRxiv

Precursors of nerve-insulating cells did not die

Researchers found no precursor cell death during development, adulthood or aging, or during myelin repair and acute body-wide inflammation.Researchers found no precursor cell death during development, adulthood or aging, or during myelin repair and acute body-wide inflammation.

Intact branching precursor cells sit beside nerve fibers with full and partial insulating wraps, clustered immune cells, and a small rodent.
Preprint: experiments in animalsMechanisms
Paper
PsyArXiv

Tailored program reduced perceived stress in adults

Perceived stress fell 18.7% 12 weeks after the tailored program, with greater reductions than in assessment-only and education groups.Perceived stress fell 18.7% 12 weeks after the tailored program, with greater reductions than in assessment-only and education groups.

Faceless adults in dark blue-green gather beneath loose curls, while smaller gray and light blue groups stand beneath dense black tangles.
Preprint: randomized trial · 426 peopleSTRESS
Paper
Journal of Hospital Medicine

30-day readmissions miss wider outcomes in older adults

Among community-dwelling patients aged 65 or older discharged home from Veterans Affairs hospitals after medical or neurological admissions, 71.1% had no acute care use…Among community-dwelling patients aged 65 or older discharged home from Veterans Affairs hospitals after medical or neurological admissions, 71.1% had no acute care use within 30 days.

Figure from Journal of Hospital Medicine
Cohort · 99,778 peoplePopulations
Paper