A cell experiment using mouse colon organoids linked gains in certain DNA marks to biological aging rather than activation of a cancer-linked mutation.A cell experiment using mouse colon organoids linked gains in certain DNA marks to biological aging rather than activation of a cancer-linked mutation.
Who was studiedSingle stem cell-derived mouse colon organoid clones
What changedAge-linked promoter DNA marks did not accelerate in mutation-activated organoids versus controls and accumulated independently of DNA copying
The catchThe reported comparison manipulated a cancer-linked mutation rather than DNA copying directly
A case-control study estimated that physical stress burden accounted for 17.0% of the association between an environmental exposure score and exposure-related cancers…A case-control study estimated that physical stress burden accounted for 17.0% of the association between an environmental exposure score and exposure-related cancers diagnosed before 50.
An observational analysis of 73 head and neck cancer patients aged 18 to 91 linked age mainly to differences in cell abundance and organization.An observational analysis of 73 head and neck cancer patients aged 18 to 91 linked age mainly to differences in cell abundance and organization.
Image-based age estimates differed from actual ages by a mean absolute error of 0.78 months in rats excluded from model training.Image-based age estimates differed from actual ages by a mean absolute error of 0.78 months in rats excluded from model training.
In FinnGen, genetically predicted hip and thigh fat, adjusted for body size, was associated with lower liver cancer odds, with an odds ratio of 0.444.In FinnGen, genetically predicted hip and thigh fat, adjusted for body size, was associated with lower liver cancer odds, with an odds ratio of 0.444.
A 12-week randomized trial of 69 adults aged 60–85 found differences between groups in breathing-muscle strength and selected biological markers, but not lung function.A 12-week randomized trial of 69 adults aged 60–85 found differences between groups in breathing-muscle strength and selected biological markers, but not lung function.
Each 29-minute increase in night-to-night sleep-duration variability was linked to higher cardiovascular risk, with a hazard ratio (a relative risk measure) of 1.24.Each 29-minute increase in night-to-night sleep-duration variability was linked to higher cardiovascular risk, with a hazard ratio (a relative risk measure) of 1.24.
