Tailored program reduced perceived stress in adults
Perceived stress fell 18.7% 12 weeks after the tailored program, with greater reductions than in assessment-only and education groups.

Registered NCT06063174
Limit: Immediately after treatment, perceived stress did not clearly differ from the education group
Edited by Boris Djordjevic · AgingResearch.News
In a randomized trial, 426 adults aged 18–86 were assigned to a tailored stress program, education about reducing environmental toxins, or assessments alone. The fully remote, 12-week program targeted each participant’s main stress-related problem: thinking style, social relationships, sleep, eating or physical activity.
Participants receiving the tailored program had a 15.9% reduction in perceived stress immediately afterward and an 18.7% reduction 12 weeks later. Reductions were greater than with assessments alone at both time points. Compared with the education group, the estimated benefit immediately afterward had a range of likely values that included no difference. At the later follow-up, the program produced a greater reduction than education.
Why it matters
Stress is linked to chronic disease risk and death, making its management relevant to questions about healthy aging.
Caveats
The abstract reports perceived stress outcomes rather than effects on disease or lifespan, and gives no information about harms. This preprint has not been peer-reviewed, and the findings do not establish effects outside ages 18–86.
The paper
Precision Intervention for Stress and Resilience (PRECISE): A Randomized Clinical Trial
PsyArXiv, Nov 2, 2026, Open access, Preprint, not peer-reviewed

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