Bioinformation · Oct 31, 2026
Association of thyroid dysfunction with metabolic syndrome: A cross-sectional study
By Harshavardhan K
Thyroid dysfunction may contribute to cardiometabolic risk, but its association with metabolic syndrome remains clinically important. This cross-sectional study evaluated 153 adults attending a tertiary care hospital using serum thyroid stimulating hormone, free triiodothyronine and free thyroxine levels, with metabolic syndrome defined by National Cholesterol Education Program Adult Treatment Panel III criteria. Metabolic syndrome was significantly more prevalent in hypothyroidism (61.0%) than euthyroidism (31.9%) or hyperthyroidism (27.8%; p=0.003), with hypothyroid participants also showing higher fasting blood glucose, waist circumference and triglycerides and lower high-density lipoprotein cholesterol. Serum thyroid-stimulating hormone showed positive relationships with waist circumference and triglyceride levels, supporting an association between hypothyroidism and adverse cardiometabolic risk. These findings advance knowledge by highlighting early thyroid function assessment as a potential strategy for improved cardiometabolic risk classification and management.