5 papers4 findings
Exercise
upin humans1
Exercise improves peak oxygen uptake in humans.
Human trialhealthy aging2 years
Scandinavian journal of medicine & science in sports1 Sep 2026
Aerobic exercise
upin humans1
Aerobic exercise increases peak oxygen uptake in humans (MD = 3.99 ml/kg/min, 95% CI: 2.01, 5.96).
Human trialversus non-aerobic exercise
Annals of Indian Academy of Neurology18 May 2026
Older age
downin humans1
Older age decreases peak oxygen uptake in humans.
Humansduring cardiopulmonary exercise testingn = 526
The ventilatory response pattern to exercise across the age-span in healthy adults
Physiological reports1 Sep 2026
Spermidine
upin humans1
Spermidine is associated with peak oxygen uptake in humans (β 2.6 mL·kg−1·min−1, 95% CI 0.9-4.4).
Humansin older patients with coronary artery diseaseeach doubling of dietary intaken = 187
Spermidine is linked to higher fitness in coronary artery disease
European heart journal open21 Sep 2026
Each doubling of spermidine intake was associated with 2.6 millilitres per kilogram per minute higher peak oxygen uptake in older people with coronary artery disease.Each doubling of spermidine intake was associated with 2.6 millilitres per kilogram per minute higher peak oxygen uptake in older people with coronary artery disease.
In an external validation cohort, predicted peak VO₂ correlated with observed values at r = 0.654, with a root mean square error of 4.73 mL/kg/min.In an external validation cohort, predicted peak VO₂ correlated with observed values at r = 0.654, with a root mean square error of 4.73 mL/kg/min.