Prehabilitation

2 papers3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Outcomes

Timed Up and Go completion time

downin humans1

1 study

Prehabilitation decreases timed Up and Go completion time in humans (1.57 s faster, 95% CI 0.86-2.28).
“Timed Up and Go performance also favored prehabilitation (six trials; 389 participants; mean difference 1.57 s faster, 95% CI 0.86-2.28; I2 = 0%).”
Reviewtotal hip or knee arthroplastyphysical or multimodaln = 389
Prehabilitation for Adults Undergoing Lower-Extremity Total Joint Arthroplasty: A Systematic Review and Meta-Analysis
Research in nursing & health12 Oct 2026

Early performance-based physical function

upin humans1

1 study

Prehabilitation improves early performance-based physical function in humans (g = 0.48, 95% CI 0.07-0.90).
“Early performance-based physical function favored prehabilitation on average (10 trials; 581 participants; g = 0.48, 95% CI 0.07-0.90; I2 = 76.7%)”
Reviewtotal hip or knee arthroplasty; prediction interval crossed the null and restricted analysis was inconclusivephysical or multimodaln = 581
Prehabilitation for Adults Undergoing Lower-Extremity Total Joint Arthroplasty: A Systematic Review and Meta-Analysis
Research in nursing & health12 Oct 2026

Early patient-reported physical function

no changein humans1

1 study

Prehabilitation has no effect on early patient-reported physical function in humans (Hedges' g = 0.33, 95% CI -0.23 to 0.89; no clear benefit).
“Early patient-reported physical function showed no clear benefit (six trials; 327 participants; Hedges' g = 0.33, 95% CI -0.23 to 0.89; I2 = 70.2%).”
Reviewtotal hip or knee arthroplastyphysical or multimodaln = 327
Prehabilitation for Adults Undergoing Lower-Extremity Total Joint Arthroplasty: A Systematic Review and Meta-Analysis
Research in nursing & health12 Oct 2026