Fibrotic interstitial lung disease

1. Fibrotic interstitial lung disease decreases free androgen index in humans (0.51 vs 1.23, p=0.0036).

   “Mean free androgen index (FAI) was low for female patients but not ASMCs (mean 0.51 [95%CI:0.35-0.67] vs 1.23 [95%CI:0.77-1.69]; p=0.0036, N=22).”

   Humansin female F-ILD patients vs ASMCsfemalesn = 22

   STARSHIP: Study of Telomeres And Role of Sex Hormones In Pulmonary fibrosis

   medRxiv·Aug 5, 2026Preprint

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1. Fibrotic interstitial lung disease decreases bioavailable testosterone in humans (4.95nmol/L vs 6.40nmol/L, p<0.0001).

   “Mean bioavailable testosterone was lower for N=80 male patients than ASMCs (4.95nmol/L [95%CI:4.50-5.41] vs 6.40nmol/L [95%CI:5.82-6.98]; p<0.0001).”

   Humansin male F-ILD patients vs ASMCsmalesn = 80

   STARSHIP: Study of Telomeres And Role of Sex Hormones In Pulmonary fibrosis

   medRxiv·Aug 5, 2026Preprint

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1. Fibrotic interstitial lung disease decreases telomere length in humans (4.57kb vs 4.78kb, p<0.006).

   “Mean LTL was shorter for patients than ASMCs (4.57kb [95%CI:4.46-4.69] vs 4.78kb [95%CI:4.67-4.89]; p<0.006).”

   Humanspatients presenting with F-ILD compared to ASMCsleukocytes

   STARSHIP: Study of Telomeres And Role of Sex Hormones In Pulmonary fibrosis

   medRxiv·Aug 5, 2026Preprint

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